{"id":"W1558649589","doi":"10.4049/jimmunol.1403145","title":"Quantitative TCR:pMHC Dissociation Rate Assessment by NTAmers Reveals Antimelanoma T Cell Repertoires Enriched for High Functional Competence","year":2015,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research","keywords":"Avidity; T-cell receptor; CD8; T cell; Cytotoxic T cell; Peptide; Biology; Immune system; Antigen; Molecular biology; Chemistry; Cell biology; Immunology; Biochemistry; In vitro","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002734153,0.0001350865,0.0004391407,0.0001305713,0.0001319401,0.00001716377,0.0002095727,0.000098511,0.0003090943],"category_scores_gemma":[0.0004716225,0.00008761235,0.0001214729,0.0001756259,0.0002207149,0.0001190453,0.00004501364,0.0004566448,0.0000146784],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003897759,"about_ca_system_score_gemma":0.0004194707,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008904526,"about_ca_topic_score_gemma":0.000004249763,"domain_scores_codex":[0.9980196,0.0006855082,0.0005113126,0.0001219041,0.0003823626,0.0002792674],"domain_scores_gemma":[0.996897,0.001298799,0.0006148271,0.0002158353,0.0008873643,0.00008616907],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.005537109,0.0002072179,0.00215567,0.00001348954,0.0004922677,0.00001016673,0.0006372133,0.00003783962,0.9748635,0.0005484531,0.01435917,0.001137873],"study_design_scores_gemma":[0.04929917,0.04794833,0.5644484,0.0003821919,0.001666559,0.001848317,0.02545016,0.002185769,0.2642369,0.01561394,0.02590154,0.001018693],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.984586,0.002612355,0.004899551,0.00633493,0.0005455235,0.000402575,0.00001602934,0.00001146291,0.0005915894],"genre_scores_gemma":[0.9915472,0.0008101535,0.001827034,0.0003275413,0.0001436455,0.00001050119,0.00003657933,0.00002284094,0.005274454],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7106266,"threshold_uncertainty_score":0.3572728,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04405224908136289,"score_gpt":0.3410983550013257,"score_spread":0.2970461059199628,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}