{"id":"W1558649589","doi":"10.4049/jimmunol.1403145","title":"Quantitative TCR:pMHC Dissociation Rate Assessment by NTAmers Reveals Antimelanoma T Cell Repertoires Enriched for High Functional Competence","year":2015,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research","keywords":"Avidity; T-cell receptor; CD8; T cell; Cytotoxic T cell; Peptide; Biology; Immune system; Antigen; Molecular biology; Chemistry; Cell biology; Immunology; Biochemistry; In vitro","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002326316,0.0002221228,0.0002448334,0.0002610389,0.00008727516,0.0002314674,0.00007922141,0.0002398082,0.0008965385],"category_scores_gemma":[0.0003200382,0.0001007632,0.00009222217,0.0001231598,0.0001178443,0.0001577506,0.0001256732,0.0003445614,0.0002585778],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009642498,"about_ca_system_score_gemma":0.00005045493,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001038564,"about_ca_topic_score_gemma":0.0001503879,"domain_scores_codex":[0.9997823,0.00004168435,0.00001867695,0.00007463255,0.00004652093,0.00003624259],"domain_scores_gemma":[0.9998024,0.00007949558,0.00004249382,0.00002295452,0.00002824868,0.00002432139],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000078326,0.000007521795,0.001330994,0.000009344346,0.000002247126,0.000006732412,0.00001537673,0.00005652893,0.9972753,0.000008931842,0.000004022772,0.00120468],"study_design_scores_gemma":[0.000008346804,0.0005127951,0.032623,0.000004488451,0.00002223754,0.0004316095,0.00004406696,0.004230397,0.9614214,0.00005264688,0.0006444817,0.000004597132],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951342,0.0003181032,0.004047142,0.00000864455,0.000002945469,0.00001469789,0.0000816529,0.0000231571,0.0003695575],"genre_scores_gemma":[0.9969708,0.0001072816,0.002414786,0.00001133915,0.00000313454,0.00002289392,0.0001434086,0.000009744531,0.0003166466],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008965385,"threshold_uncertainty_score":0.002999246,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04405224908136289,"score_gpt":0.3410983550013257,"score_spread":0.2970461059199628,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}