{"id":"W1558836596","doi":"10.1002/jcph.326","title":"Pharmacokinetics, pharmacodynamics, and safety of pasireotide LAR in patients with acromegaly: A randomized, multicenter, open‐label, phase I study","year":2014,"lang":"en","type":"article","venue":"The Journal of Clinical Pharmacology","topic":"Pituitary Gland Disorders and Treatments","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôpital Notre-Dame","funders":"Novartis Pharmaceuticals Corporation; Novartis","keywords":"Pasireotide; Acromegaly; Medicine; Tolerability; Pharmacokinetics; Adverse effect; Pharmacodynamics; Internal medicine; Octreotide; Gastroenterology; Somatostatin; Randomized controlled trial; Pharmacology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001719713,0.001041392,0.001721602,0.0002425707,0.0002841173,0.0006749797,0.0004373749,0.0007152662,0.001663383],"category_scores_gemma":[0.001306833,0.0005664722,0.00107045,0.0002551733,0.001001483,0.0007843341,0.0002105114,0.001773089,0.0003719385],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005657478,"about_ca_system_score_gemma":0.0008914388,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003951399,"about_ca_topic_score_gemma":0.0006669002,"domain_scores_codex":[0.9993574,0.0003325639,0.00004118599,0.00009726785,0.00008169984,0.00008977894],"domain_scores_gemma":[0.9990392,0.0002282885,0.0002734702,0.00008970338,0.00005111875,0.000318345],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8266357,0.05041885,0.006636761,0.0003523335,0.0007954533,0.0001890654,0.0002383087,0.002033439,0.05894079,0.0001587341,0.0008826476,0.05271792],"study_design_scores_gemma":[0.3503517,0.6269371,0.01553669,0.00001600595,0.0003805986,0.0002077525,0.00005078737,0.001950124,0.003551801,0.0001187133,0.0008594858,0.00003926483],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978756,0.000549202,0.0004226409,0.00007748239,0.00002950468,0.0005571392,0.0001539163,0.00003706102,0.0002975295],"genre_scores_gemma":[0.9971341,0.0003697259,0.0007963658,0.0001951225,0.00008342576,0.000667605,0.0003320526,0.00001158004,0.0004099188],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001721602,"threshold_uncertainty_score":0.009094834,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03529810473432504,"score_gpt":0.4234314662478706,"score_spread":0.3881333615135455,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}