{"id":"W1560126339","doi":"10.1074/jbc.m114.621292","title":"Functional Genomic Screen Identifies Klebsiella pneumoniae Factors Implicated in Blocking Nuclear Factor κB (NF-κB) Signaling","year":2015,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":59,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Instituto de Salud Carlos III; Biotechnology and Biological Sciences Research Council; Directorate for Biological Sciences; Ministerio de Ciencia e Innovación; Queen's University; Queen's University Belfast","keywords":"Biology; Microbiology; Mutant; TLR2; Klebsiella pneumoniae; Innate immune system; TLR4; Klebsiella pneumonia; Immune system; Signal transduction; Gene; Cell biology; Escherichia coli; Biochemistry; Immunology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002118088,0.0007360409,0.0005763213,0.0006022496,0.0001766003,0.000374669,0.00035387,0.0003339352,0.001223977],"category_scores_gemma":[0.0002759894,0.0001961596,0.0005463968,0.0005796592,0.0001680239,0.0001216835,0.0003224839,0.0003897348,0.0004601949],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002805852,"about_ca_system_score_gemma":0.0003508416,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001039635,"about_ca_topic_score_gemma":0.001337196,"domain_scores_codex":[0.9996618,0.000045672,0.00004202008,0.00005535501,0.0001285623,0.00006647329],"domain_scores_gemma":[0.9997889,0.00006025873,0.00005575759,0.00002046246,0.00003530173,0.00003925409],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007558842,0.00005898774,0.0002828159,0.00003387148,0.000008825604,0.00008092403,0.000008175274,0.00006111432,0.9984822,0.00001842449,0.00002157835,0.0008675686],"study_design_scores_gemma":[0.00002685601,0.001028379,0.01183222,0.00001098079,0.00009685362,0.0007246102,0.00007426974,0.00123269,0.9831209,0.00004071867,0.001797532,0.00001410376],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9903451,0.0009201795,0.004832105,0.0001025047,0.00002503014,0.0001139165,0.002447299,0.0002054833,0.001008495],"genre_scores_gemma":[0.9831202,0.0009992692,0.00813249,0.0000872005,0.00000942655,0.00009202272,0.005145233,0.00007367773,0.002340498],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001223977,"threshold_uncertainty_score":0.004094601,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04148334599230633,"score_gpt":0.2589329707064998,"score_spread":0.2174496247141935,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}