{"id":"W1560588280","doi":"10.1002/cncr.28933","title":"Performance characteristics of screening strategies for Lynch syndrome in unselected women with newly diagnosed endometrial cancer who have undergone universal germline mutation testing","year":2014,"lang":"en","type":"article","venue":"Cancer","topic":"Genetic factors in colorectal cancer","field":"Medicine","cited_by":141,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Juravinski Hospital; Mount Sinai Hospital; Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"Princess Margaret Hospital Foundation","keywords":"Lynch syndrome; MSH6; Microsatellite instability; Medicine; MSH2; MLH1; Germline mutation; Endometrial cancer; Family history; Genetic testing; Oncology; Internal medicine; Cancer; Gynecology; Mutation; DNA mismatch repair; Genetics; Biology; Colorectal cancer; Microsatellite","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002300243,0.0002268683,0.0005729108,0.0002855947,0.00006100811,0.0000211896,0.0001078646,0.0001156041,0.0001008947],"category_scores_gemma":[0.0003677542,0.0002053778,0.00003317634,0.0007269016,0.0001274359,0.0001488646,0.00002132968,0.0002074833,4.886408e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005746764,"about_ca_system_score_gemma":0.0008239598,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000754239,"about_ca_topic_score_gemma":0.0006211597,"domain_scores_codex":[0.9984807,0.0000431234,0.000399572,0.0003349753,0.0003025185,0.0004391625],"domain_scores_gemma":[0.99841,0.0005402681,0.0003093417,0.0001805161,0.0004465417,0.0001132907],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0135534,0.0002284409,0.7012404,0.002028495,0.0004811383,0.00007696859,0.004336638,0.04276035,0.03337555,0.00007877847,0.0001165692,0.2017233],"study_design_scores_gemma":[0.01317232,0.003767183,0.8961188,0.001389727,0.0001630581,0.00003137349,0.0008382388,0.0795147,0.004373207,0.00003022207,0.0002217363,0.0003794392],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924833,0.0001669317,0.005999699,0.00007816013,0.0001985681,0.0008000931,0.00006949094,0.00004006073,0.0001637543],"genre_scores_gemma":[0.9957709,0.0001057675,0.003109313,0.00008360652,0.000253423,0.0004012733,0.00004506936,0.00005123558,0.0001794644],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2013438,"threshold_uncertainty_score":0.8375062,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0258742533403907,"score_gpt":0.2726790943631391,"score_spread":0.2468048410227484,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}