{"id":"W1561070512","doi":"10.3389/fimmu.2015.00355","title":"IL-15–PI3K–AKT–mTOR: A Critical Pathway in the Life Journey of Natural Killer Cells","year":2015,"lang":"en","type":"review","venue":"Frontiers in Immunology","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":140,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Canada Research Chairs","keywords":"PI3K/AKT/mTOR pathway; Protein kinase B; Cell biology; Interleukin 15; Signal transduction; Biology; Effector; Cancer research; Interleukin 12; Immunology; Cytokine; Interleukin; Cytotoxic T cell; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002508897,0.0006696077,0.0007631661,0.001118752,0.0002612471,0.0008556189,0.0006064204,0.0007972996,0.001624798],"category_scores_gemma":[0.0002089142,0.0002230932,0.0002681007,0.001019928,0.0003898961,0.001155134,0.0005917701,0.001404172,0.001658007],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006344492,"about_ca_system_score_gemma":0.0009134028,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004622419,"about_ca_topic_score_gemma":0.0007338077,"domain_scores_codex":[0.9998944,0.00001215749,0.00001677093,0.00002003939,0.00004123336,0.00001533028],"domain_scores_gemma":[0.999934,0.00001741319,0.00001291211,0.000002137794,0.00002123699,0.00001236818],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001048866,0.00005181307,0.0001624415,0.01155244,0.00006047323,0.000275639,0.00007182578,0.0003343296,0.008268134,0.00690732,0.01967286,0.9525378],"study_design_scores_gemma":[0.00001274044,0.00006402138,0.0007349873,0.001196348,0.00003806506,0.001121451,0.00005309062,0.00008319114,0.001783571,0.002547804,0.9923499,0.00001477319],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002451027,0.9977015,0.0002294572,0.0003229108,0.0002782412,0.000005256712,0.0000174917,0.00001074388,0.001189425],"genre_scores_gemma":[0.001361469,0.9971972,0.0002610144,0.0001723077,0.0001531196,0.000006359176,0.00003339535,0.000001395367,0.0008139059],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001624798,"threshold_uncertainty_score":0.005435467,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02658808571246288,"score_gpt":0.2864708853517987,"score_spread":0.2598827996393358,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}