{"id":"W1561228988","doi":"10.3329/jce.v24i0.5577","title":"An Oxygen Transport Model of Human Bone Marrow for Hemolytic Sickle Cell Anemia","year":2010,"lang":"en","type":"article","venue":"Journal of Chemical Engineering","topic":"Hemoglobin structure and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Commonwealth Scholarship Commission","keywords":"Haematopoiesis; Bone marrow; Oxygen tension; Hemoglobin; Sickle cell anemia; Hemolytic anemia; Oxygen transport; Anemia; Oxygen; In vivo; Cell; Human bone; Chemistry; Allosteric regulation; Immunology; Biology; Medicine; Cell biology; Biochemistry; Stem cell; Internal medicine; In vitro; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002913709,0.0006203449,0.0009036995,0.0004990018,0.0007165499,0.001016708,0.001506113,0.002656093,0.006521057],"category_scores_gemma":[0.0006040884,0.0003637813,0.0008644681,0.0004944385,0.0006829457,0.0009893017,0.0009906471,0.0007775946,0.0005567627],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001312453,"about_ca_system_score_gemma":0.001320315,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01978884,"about_ca_topic_score_gemma":0.006958423,"domain_scores_codex":[0.999876,0.00003231629,0.000005856902,0.00002829768,0.000027287,0.00003024783],"domain_scores_gemma":[0.9997968,0.0000618469,0.00003740923,0.000008645586,0.00005581656,0.00003950961],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0001810293,0.00008606596,0.0008018674,0.0001052267,0.00002899292,0.0005777592,0.0001602696,0.9208215,0.009550321,0.0644208,0.001264449,0.00200175],"study_design_scores_gemma":[0.00004706656,0.00003411095,0.0001961286,0.000008367344,0.00001192497,0.00004015505,0.00003330371,0.9944153,0.0002775951,0.003804927,0.001120094,0.00001097036],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5597036,0.004547589,0.3099712,0.008197715,0.0007113118,0.0003631184,0.003589008,0.0004987075,0.1124178],"genre_scores_gemma":[0.9319955,0.001604674,0.01261671,0.0004762922,0.00008563275,0.000428708,0.0008260124,0.00007313473,0.05189332],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01978884,"threshold_uncertainty_score":0.03934729,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004697138417835827,"score_gpt":0.2107883287608523,"score_spread":0.2060911903430164,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}