{"id":"W1561282213","doi":"10.1186/ar1349","title":"Post-transcriptional regulation of tumor necrosis factor alpha expression","year":2004,"lang":"en","type":"article","venue":"Arthritis Research","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Arthritis Network; National Cancer Institute; Genentech; National Institutes of Health; Natural Sciences and Engineering Research Council of Canada; Dutch Arthritis Association; Oesterreichische Nationalbank; Deutsche Forschungsgemeinschaft; Nuffield Foundation; Arthritis Society; Physiotherapy Foundation of Canada; Canadian Institutes of Health Research; Lupus Research Alliance; Wellcome Trust; National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute of Allergy and Infectious Diseases; Howard Hughes Medical Institute; Lupus Research Institute; Biogen; Austrian Science Fund; Arthritis Foundation","keywords":"Tristetraprolin; Phosphorylation; p38 mitogen-activated protein kinases; Tumor necrosis factor alpha; Untranslated region; Cytokine; Messenger RNA; Translation (biology); Cell biology; Kinase; Zinc finger; MAPK/ERK pathway; Chemistry; RNA-binding protein; Post-transcriptional regulation; Signal transduction; AU-rich element; Biology; Transcription factor; Gene; Biochemistry; Immunology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00039767,0.00008537338,0.0001083102,0.0001236701,0.0001712854,0.00003405842,0.0001979483,0.00008428512,0.0001670905],"category_scores_gemma":[0.0002602441,0.00008197455,0.00008083858,0.0001579379,0.0001925308,0.00001386544,0.0001024524,0.0001747834,0.00003252985],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003940234,"about_ca_system_score_gemma":0.0003161739,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003401603,"about_ca_topic_score_gemma":0.0001812395,"domain_scores_codex":[0.9983779,0.0001122869,0.0001993056,0.0002890209,0.0006251744,0.000396301],"domain_scores_gemma":[0.9990341,0.0000212578,0.00002976178,0.0002855931,0.0004857671,0.0001435205],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001634213,0.00007802063,0.0008593922,0.0000169467,0.000008835516,0.000005430894,0.00007208415,0.0000280911,0.9921133,0.0004783959,0.0002614365,0.005914655],"study_design_scores_gemma":[0.000981044,0.0005889105,0.02969803,0.00009248325,5.317791e-7,0.00001378299,0.00006554084,0.00001108009,0.9640914,0.000562623,0.003807188,0.00008740286],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973451,0.0009671771,0.000423126,0.0003568953,0.00003642821,0.0002237494,0.00007039756,0.000007747074,0.0005693957],"genre_scores_gemma":[0.9970729,0.0004225865,0.0008769716,0.00004034992,0.0001099608,0.00003118739,0.0001159879,0.00001702325,0.001313061],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02883863,"threshold_uncertainty_score":0.3342825,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02762637723509314,"score_gpt":0.3227986312170906,"score_spread":0.2951722539819975,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}