{"id":"W1561282213","doi":"10.1186/ar1349","title":"Post-transcriptional regulation of tumor necrosis factor alpha expression","year":2004,"lang":"en","type":"article","venue":"Arthritis Research","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Arthritis Network; National Cancer Institute; Genentech; National Institutes of Health; Natural Sciences and Engineering Research Council of Canada; Dutch Arthritis Association; Oesterreichische Nationalbank; Deutsche Forschungsgemeinschaft; Nuffield Foundation; Arthritis Society; Physiotherapy Foundation of Canada; Canadian Institutes of Health Research; Lupus Research Alliance; Wellcome Trust; National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute of Allergy and Infectious Diseases; Howard Hughes Medical Institute; Lupus Research Institute; Biogen; Austrian Science Fund; Arthritis Foundation","keywords":"Tristetraprolin; Phosphorylation; p38 mitogen-activated protein kinases; Tumor necrosis factor alpha; Untranslated region; Cytokine; Messenger RNA; Translation (biology); Cell biology; Kinase; Zinc finger; MAPK/ERK pathway; Chemistry; RNA-binding protein; Post-transcriptional regulation; Signal transduction; AU-rich element; Biology; Transcription factor; Gene; Biochemistry; Immunology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005611808,0.0002542992,0.0002187371,0.0004735718,0.0002195023,0.0008709237,0.0001452091,0.0001963711,0.001413109],"category_scores_gemma":[0.0004687964,0.0001423804,0.000406983,0.0002960342,0.000317385,0.0002540045,0.000272647,0.0004760541,0.001076896],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005684556,"about_ca_system_score_gemma":0.0003496389,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007707694,"about_ca_topic_score_gemma":0.0007737712,"domain_scores_codex":[0.9994765,0.000132054,0.00003438263,0.0001621393,0.0001111855,0.00008374584],"domain_scores_gemma":[0.9995311,0.0001143313,0.0001289045,0.00004699048,0.0001359715,0.00004267867],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005169683,0.0000713914,0.003230684,0.0001591026,0.00002489257,0.0001614884,0.0001255331,0.0002199333,0.9769298,0.001592331,0.0007271548,0.0162407],"study_design_scores_gemma":[0.00005800799,0.0005916409,0.05445802,0.0001012624,0.00006558139,0.0005330145,0.0003189761,0.002938946,0.9138176,0.001023788,0.02607208,0.00002105429],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9112408,0.03055823,0.03437898,0.001542067,0.001243047,0.0001367802,0.003490119,0.0004486491,0.01696129],"genre_scores_gemma":[0.9726021,0.007088541,0.006372317,0.0001910035,0.0001100091,0.00005584575,0.002131529,0.00004848069,0.01140021],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001413109,"threshold_uncertainty_score":0.004727304,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02762637723509314,"score_gpt":0.3227986312170906,"score_spread":0.2951722539819975,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}