{"id":"W1561337118","doi":"10.1111/cas.12703","title":"Atonal homolog 1 protein stabilized by tumor necrosis factor α induces high malignant potential in colon cancer cell line","year":2015,"lang":"en","type":"article","venue":"Cancer Science","topic":"NF-κB Signaling Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Japan Science and Technology Agency; Ministry of Health, Labour and Welfare; Japan Society for the Promotion of Science; Ministry of Education, Culture, Sports, Science and Technology; Japan Foundation for Applied Enzymology; Research Center Network for Realization of Regenerative Medicine; Japan Agency for Medical Research and Development","keywords":"Cancer research; Colorectal cancer; Carcinogenesis; LGR5; Cancer; Cancer stem cell; Cell; Tumor necrosis factor alpha; Cell cycle; Biology; Medicine; Immunology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003746998,0.000195133,0.0001997101,0.00004970975,0.0001014401,0.00006443392,0.0005971319,0.0001069293,0.0001350642],"category_scores_gemma":[0.00007624432,0.0001736942,0.00004296641,0.0003446645,0.0004854327,0.00002388363,0.0002263775,0.0001258936,0.000006398348],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002588606,"about_ca_system_score_gemma":0.001739744,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003770131,"about_ca_topic_score_gemma":0.0006927162,"domain_scores_codex":[0.9980741,0.00005871313,0.0002476809,0.000701785,0.0004059305,0.0005118102],"domain_scores_gemma":[0.9990658,0.000005507908,0.0001446059,0.0003126297,0.0002380417,0.0002334772],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001020953,0.00007473867,0.001190076,0.0000131325,0.000004076388,0.000008588926,0.00009658496,0.000226061,0.9973704,0.000007976127,0.0005326394,0.0003736065],"study_design_scores_gemma":[0.0009158846,0.000295663,0.000720471,0.00003185894,0.000005786924,0.000003112176,0.00005011811,0.0001500403,0.996184,0.00004616354,0.001344924,0.0002519767],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964885,0.001895948,0.0001624166,0.0001968486,0.0004999884,0.0003960895,0.0002697834,0.00001639975,0.00007405293],"genre_scores_gemma":[0.998251,0.00006514278,0.0004672537,0.0002435295,0.0001402566,0.000279933,0.00001926254,0.00001858917,0.000515004],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003077414,"threshold_uncertainty_score":0.7083044,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02178273862212609,"score_gpt":0.2749753971839861,"score_spread":0.25319265856186,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}