{"id":"W1561337118","doi":"10.1111/cas.12703","title":"Atonal homolog 1 protein stabilized by tumor necrosis factor α induces high malignant potential in colon cancer cell line","year":2015,"lang":"en","type":"article","venue":"Cancer Science","topic":"NF-κB Signaling Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Japan Science and Technology Agency; Ministry of Health, Labour and Welfare; Japan Society for the Promotion of Science; Ministry of Education, Culture, Sports, Science and Technology; Japan Foundation for Applied Enzymology; Research Center Network for Realization of Regenerative Medicine; Japan Agency for Medical Research and Development","keywords":"Cancer research; Colorectal cancer; Carcinogenesis; LGR5; Cancer; Cancer stem cell; Cell; Tumor necrosis factor alpha; Cell cycle; Biology; Medicine; Immunology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008293311,0.0002044634,0.0001839455,0.0002230154,0.0002169328,0.0001928872,0.00009833308,0.0001726782,0.001767733],"category_scores_gemma":[0.00008516537,0.00008278836,0.000193159,0.0002229765,0.0001518619,0.00009536815,0.0001204425,0.0004462811,0.0003994354],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002008787,"about_ca_system_score_gemma":0.0001701907,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007297564,"about_ca_topic_score_gemma":0.001012571,"domain_scores_codex":[0.9998893,0.00001572934,0.00001162726,0.00002127176,0.00003782937,0.00002429096],"domain_scores_gemma":[0.9999273,0.00001089037,0.00001605122,0.00001426384,0.00001054446,0.00002096809],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001577863,0.00005777853,0.0004150015,0.0000426896,0.000005660938,0.0001101006,0.00002207548,0.00003727976,0.9983084,0.00007445426,0.0001367086,0.000631964],"study_design_scores_gemma":[0.0000529148,0.0008246333,0.01175535,0.000009301722,0.00002528557,0.0006725424,0.00007736168,0.001180892,0.980547,0.00006840751,0.004780705,0.000005656326],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944397,0.001741069,0.001145119,0.0001457858,0.00007001528,0.00003190306,0.0005404999,0.00005960185,0.001826339],"genre_scores_gemma":[0.9943334,0.0008010417,0.0008184206,0.00006174162,0.00001014362,0.00004556311,0.001050253,0.000009000265,0.002870461],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001767733,"threshold_uncertainty_score":0.005913615,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02178273862212609,"score_gpt":0.2749753971839861,"score_spread":0.25319265856186,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}