{"id":"W1561438795","doi":"10.1111/j.1742-7843.2010.00639.x","title":"The Calcium-Sensing Receptor Mediates Hypoxia-Induced Proliferation of Rat Pulmonary Artery Smooth Muscle Cells Through MEK1/ERK1,2 and PI3K Pathways","year":2010,"lang":"en","type":"article","venue":"Basic & Clinical Pharmacology & Toxicology","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lakehead University","funders":"","keywords":"Calcium-sensing receptor; Protein kinase B; Cell growth; Intracellular; Proliferating cell nuclear antigen; Calcium in biology; Blot; Extracellular; Kinase; PI3K/AKT/mTOR pathway; Cell biology; Hypoxia (environmental); Mitogen-Activated Protein Kinase 3; Molecular biology; Biology; Calcium; Chemistry; Signal transduction; Internal medicine; MAPK/ERK pathway; Calcium metabolism; Medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001256246,0.0003078784,0.0003213587,0.0001787813,0.0001670306,0.0002065895,0.0001687765,0.0001660095,0.001342041],"category_scores_gemma":[0.0001002711,0.0001497387,0.0004268891,0.0001357022,0.0001376061,0.0002331974,0.0001803591,0.0005680001,0.0004380753],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002157341,"about_ca_system_score_gemma":0.0002957825,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008963447,"about_ca_topic_score_gemma":0.001313142,"domain_scores_codex":[0.9998925,0.0000134376,0.0000100276,0.00001965612,0.00002770422,0.00003673055],"domain_scores_gemma":[0.9999595,0.000005083169,0.00001159164,0.000004274607,0.000007196789,0.00001247476],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002370439,0.00005426489,0.0001401863,0.0001019364,0.000007089984,0.00006448997,0.00001805732,0.00005661748,0.9970987,0.0001303843,0.0001047002,0.001986599],"study_design_scores_gemma":[0.0001010741,0.000654777,0.01107673,0.00001373253,0.0000540771,0.0004807316,0.00005022071,0.002568081,0.9797433,0.0001105204,0.005136618,0.00001030479],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9852585,0.005817896,0.004459911,0.0002794121,0.00006906752,0.00005560188,0.0005353684,0.0001421879,0.003382139],"genre_scores_gemma":[0.9879561,0.00338701,0.002984397,0.00006971113,0.0000358099,0.0001227778,0.0008001555,0.00001501028,0.00462894],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001342041,"threshold_uncertainty_score":0.004489541,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03774618676372314,"score_gpt":0.329459327295076,"score_spread":0.2917131405313529,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}