{"id":"W1561438795","doi":"10.1111/j.1742-7843.2010.00639.x","title":"The Calcium-Sensing Receptor Mediates Hypoxia-Induced Proliferation of Rat Pulmonary Artery Smooth Muscle Cells Through MEK1/ERK1,2 and PI3K Pathways","year":2010,"lang":"en","type":"article","venue":"Basic & Clinical Pharmacology & Toxicology","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lakehead University","funders":"","keywords":"Calcium-sensing receptor; Protein kinase B; Cell growth; Intracellular; Proliferating cell nuclear antigen; Calcium in biology; Blot; Extracellular; Kinase; PI3K/AKT/mTOR pathway; Cell biology; Hypoxia (environmental); Mitogen-Activated Protein Kinase 3; Molecular biology; Biology; Calcium; Chemistry; Signal transduction; Internal medicine; MAPK/ERK pathway; Calcium metabolism; Medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001335976,0.0003426478,0.0006256161,0.00004961284,0.0003143529,0.00002479304,0.0003614876,0.0008870428,0.000104743],"category_scores_gemma":[0.0004490449,0.0002767018,0.0002447666,0.0001230811,0.001129029,0.00002057057,0.0002751764,0.0008346969,0.00002067622],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001493939,"about_ca_system_score_gemma":0.0004032914,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001622912,"about_ca_topic_score_gemma":0.0001467444,"domain_scores_codex":[0.9966304,0.0007321528,0.001025271,0.0008145355,0.0001716818,0.0006259176],"domain_scores_gemma":[0.9977951,0.000791922,0.000464467,0.0004898507,0.0002247788,0.0002338966],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000470666,0.0003100225,0.0002949221,0.00001692332,0.0001127249,0.000006494932,0.00007462247,0.000002852084,0.9432417,0.00008483464,0.01716699,0.03821726],"study_design_scores_gemma":[0.001956946,0.0008115813,0.006842264,0.00000579829,0.0001912115,0.00003133827,0.0000765691,0.0001374757,0.6689445,0.0003594427,0.3203348,0.0003080036],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.973084,0.001376702,0.0001069785,0.001914761,0.02233578,0.0007370865,0.00003200275,0.00003313745,0.0003795392],"genre_scores_gemma":[0.9837754,0.00343012,0.0007791123,0.004177956,0.007468147,0.00007772927,0.00005849022,0.00005027074,0.0001827801],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3031678,"threshold_uncertainty_score":0.9999685,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03774618676372314,"score_gpt":0.329459327295076,"score_spread":0.2917131405313529,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}