{"id":"W1561767136","doi":"10.1111/ahg.12002","title":"Genotype‐Based Association Analysis Using Discordant Pairs: A Penetrance Odds Ratio Approach","year":2013,"lang":"en","type":"article","venue":"Annals of Human Genetics","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Dalhousie University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"McNemar's test; Odds ratio; Statistics; Score test; Penetrance; Likelihood-ratio test; Genetic association; Genotype; Biology; Mathematics; Genetics; Single-nucleotide polymorphism","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004940947,0.0001881621,0.0003684096,0.0001303677,0.0001393353,0.00003067416,0.0002362429,0.0001886249,0.00008281801],"category_scores_gemma":[0.0001419165,0.0001874835,0.0002916771,0.000303653,0.00007011871,0.000005070061,0.00006448624,0.00008484295,0.000008620597],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002145992,"about_ca_system_score_gemma":0.00007317761,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001645628,"about_ca_topic_score_gemma":0.00008198992,"domain_scores_codex":[0.9983039,0.0002196487,0.0005187514,0.0003705289,0.0002103281,0.0003768313],"domain_scores_gemma":[0.9985225,0.00003235288,0.0004592342,0.0004583447,0.0004398588,0.0000877014],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00001725295,0.0003449141,0.5130229,0.0000468163,0.001570901,4.308112e-7,0.0001500468,0.07829006,0.4003598,0.0001154506,0.005091811,0.0009896295],"study_design_scores_gemma":[0.0006391066,0.0005675851,0.8157894,0.0000102216,0.0005872283,0.000001360133,0.0002165362,0.08555872,0.09468203,0.0005406949,0.0008201344,0.0005870109],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.94115,0.0007069609,0.05709673,0.0001583888,0.00004462947,0.0002424162,0.00003666144,0.000008559392,0.0005556315],"genre_scores_gemma":[0.9887292,0.0001477277,0.009774036,0.0004434752,0.0001412074,0.00002973552,0.0003786442,0.000022309,0.0003336279],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3056777,"threshold_uncertainty_score":0.7645356,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05979904525934441,"score_gpt":0.327271996486529,"score_spread":0.2674729512271846,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}