{"id":"W1562185454","doi":"10.4049/jimmunol.174.1.475","title":"Hemozoin Induces Macrophage Chemokine Expression through Oxidative Stress-Dependent and -Independent Mechanisms","year":2005,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Malaria Research and Control","field":"Medicine","cited_by":138,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Centre hospitalier de l'Université Laval; McGill University Health Centre; Centre hospitalier universitaire de Québec","funders":"Canadian Institutes of Health Research; Penn State College of Medicine; Johns Hopkins University","keywords":"Chemokine; Hemozoin; CCL3; CXCL2; Reactive oxygen species; Biology; Cell biology; CCL13; Superoxide dismutase; CXCL10; Proinflammatory cytokine; Phosphorylation; CCL2; Molecular biology; Chemistry; Oxidative stress; Immunology; Chemokine receptor; Inflammation; Biochemistry; Plasmodium falciparum","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007294471,0.0001461077,0.0003726247,0.0001013795,0.000113266,0.00002072125,0.0002665036,0.0001305092,0.0005617506],"category_scores_gemma":[0.0001993771,0.00008090897,0.00007081349,0.00008167077,0.0001291398,0.0001993672,0.000164234,0.0008153254,0.00001955595],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008080614,"about_ca_system_score_gemma":0.0001119956,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003215165,"about_ca_topic_score_gemma":0.000008995963,"domain_scores_codex":[0.9985057,0.0002594036,0.0003924323,0.0001150745,0.0004231568,0.000304267],"domain_scores_gemma":[0.9989779,0.0001653281,0.0003129527,0.0002279669,0.0002222643,0.00009360273],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002270808,0.0002026065,0.00002806198,0.00001388715,0.0002392785,0.0001256929,0.0009056063,0.000008178111,0.9834599,0.001027581,0.0001387847,0.01157963],"study_design_scores_gemma":[0.00496093,0.001436251,0.00387222,0.0001085654,0.0001167091,0.00229505,0.001928714,0.00002578961,0.9822478,0.002324342,0.0005963566,0.00008728801],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9724578,0.007210711,0.005530755,0.01357918,0.0001391984,0.000278223,0.000005241066,0.00001142241,0.0007874601],"genre_scores_gemma":[0.9952739,0.002112892,0.001308242,0.0003946747,0.0002298381,0.000004129383,0.000001661205,0.00001423346,0.0006604628],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02281606,"threshold_uncertainty_score":0.6150775,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01436038401323723,"score_gpt":0.2790032674475528,"score_spread":0.2646428834343156,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}