{"id":"W1562185454","doi":"10.4049/jimmunol.174.1.475","title":"Hemozoin Induces Macrophage Chemokine Expression through Oxidative Stress-Dependent and -Independent Mechanisms","year":2005,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Malaria Research and Control","field":"Medicine","cited_by":138,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Centre hospitalier de l'Université Laval; McGill University Health Centre; Centre hospitalier universitaire de Québec","funders":"Canadian Institutes of Health Research; Penn State College of Medicine; Johns Hopkins University","keywords":"Chemokine; Hemozoin; CCL3; CXCL2; Reactive oxygen species; Biology; Cell biology; CCL13; Superoxide dismutase; CXCL10; Proinflammatory cytokine; Phosphorylation; CCL2; Molecular biology; Chemistry; Oxidative stress; Immunology; Chemokine receptor; Inflammation; Biochemistry; Plasmodium falciparum","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001194399,0.0002181805,0.0001066761,0.0001028238,0.00007950551,0.0001191752,0.00005237485,0.00009938038,0.0006233934],"category_scores_gemma":[0.00006120126,0.00005770523,0.0001322326,0.00006071715,0.0001659818,0.0001214303,0.0001065621,0.0001926903,0.0001050818],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001504747,"about_ca_system_score_gemma":0.0001010528,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001898139,"about_ca_topic_score_gemma":0.0004432326,"domain_scores_codex":[0.9999337,0.0000177226,0.00000416455,0.000008619797,0.00001639712,0.00001927579],"domain_scores_gemma":[0.9999434,0.000009360647,0.00002134039,0.00000493009,0.000007859666,0.00001306933],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001778033,0.00002099506,0.0003085573,0.00004829042,0.000002548847,0.0000394896,0.000009252839,0.00001431983,0.9983343,0.00003864273,0.00001866076,0.0009871785],"study_design_scores_gemma":[0.00007190499,0.001367351,0.05566055,0.00001566386,0.00002357783,0.000357709,0.00008054967,0.0007450906,0.939072,0.0001238361,0.002474583,0.000007150867],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966815,0.001653478,0.0008376031,0.00006521688,0.00001252242,0.00002300222,0.0001237343,0.00001631226,0.0005867413],"genre_scores_gemma":[0.9966685,0.001184768,0.0009059994,0.0000445495,0.00001560235,0.0000281862,0.0001573139,0.000003164673,0.0009918213],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006233934,"threshold_uncertainty_score":0.002085507,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01436038401323723,"score_gpt":0.2790032674475528,"score_spread":0.2646428834343156,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}