{"id":"W1562474156","doi":"10.1139/y09-097","title":"Nitric oxide and calcium signaling regulate myocardial tumor necrosis factor-α expression and cardiac function in sepsisThis article is one of a selection of papers published in this special issue on Calcium Signaling.","year":2010,"lang":"en","type":"review","venue":"Canadian Journal of Physiology and Pharmacology","topic":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","field":"Immunology and Microbiology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lawson Health Research Institute","funders":"Canadian Institutes of Health Research","keywords":"Tumor necrosis factor alpha; Signal transduction; p38 mitogen-activated protein kinases; MAPK/ERK pathway; Cell biology; Proinflammatory cytokine; Kinase; Nitric oxide; Nitric oxide synthase; Biology; Endocrinology; Internal medicine; Medicine; Immunology; Inflammation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002187423,0.0004009217,0.0005063969,0.0004179624,0.0002488182,0.000807244,0.0002808938,0.0005216234,0.002150644],"category_scores_gemma":[0.0002000732,0.00008835742,0.000171816,0.0004549866,0.000249013,0.0005426094,0.0003038427,0.0006780131,0.0007183005],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000419906,"about_ca_system_score_gemma":0.0006664034,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006094536,"about_ca_topic_score_gemma":0.001360164,"domain_scores_codex":[0.999907,0.0000127699,0.00000862594,0.00001533244,0.00003715719,0.00001912526],"domain_scores_gemma":[0.9998995,0.00001220804,0.00002200811,0.000001510635,0.00004074138,0.00002394491],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001425006,0.0002140947,0.001978346,0.01194257,0.0001842322,0.001439945,0.0003160746,0.00053287,0.2717919,0.005950457,0.07223775,0.6319869],"study_design_scores_gemma":[0.0001165111,0.001126216,0.02209133,0.001316578,0.0003308597,0.002926396,0.0003139873,0.0006142044,0.04679634,0.004965131,0.9193386,0.00006377023],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.007969336,0.98089,0.0008334765,0.002165029,0.004161316,0.00002427396,0.00008585829,0.00003416328,0.003836422],"genre_scores_gemma":[0.03021106,0.9542028,0.0007027627,0.000825235,0.003933981,0.00002847135,0.0001494606,0.00001645988,0.009929753],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002150644,"threshold_uncertainty_score":0.007194638,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02601556596096364,"score_gpt":0.27463928362546,"score_spread":0.2486237176644963,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}