{"id":"W1563235353","doi":"10.1371/journal.pone.0124987","title":"Characterization of Early Disease Status in Treatment-Naive Male Paediatric Patients with Fabry Disease Enrolled in a Randomized Clinical Trial","year":2015,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Lysosomal Storage Disorders Research","field":"Medicine","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Child and Family Research Institute; Hôpital du Sacré-Cœur de Montréal; Université de Montréal","funders":"NIH Clinical Center; Haukeland Universitetssjukehus; Emory University; Brigham and Women's Hospital; University College London; Univerzita Karlova v Praze; Cincinnati Children's Hospital Medical Center; Massachusetts General Hospital; School of Medicine, Emory University; Memorial Sloan-Kettering Cancer Center; Child and Family Research Institute; University of Washington; Sanofi","keywords":"Fabry disease; Globotriaosylceramide; Medicine; Renal function; Enzyme replacement therapy; Creatinine; Urology; Gastroenterology; Internal medicine; Alpha-galactosidase; Pathology; Proteinuria; Kidney; Endocrinology; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004844074,0.0007407135,0.001829799,0.000260698,0.0002787029,0.0008073839,0.0005342333,0.001139999,0.002632638],"category_scores_gemma":[0.0042549,0.0002579858,0.0009812569,0.0003592284,0.0007502821,0.0006539651,0.0003458424,0.001148554,0.0002789244],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004051547,"about_ca_system_score_gemma":0.0009665544,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001622264,"about_ca_topic_score_gemma":0.0003586229,"domain_scores_codex":[0.9972962,0.002002254,0.0001344376,0.0002528701,0.0001539413,0.0001602577],"domain_scores_gemma":[0.9967009,0.001094691,0.00121533,0.0002510092,0.000122401,0.0006156429],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9145678,0.003712547,0.05580435,0.0003270374,0.001265954,0.0001654732,0.0001038979,0.0004288193,0.003596017,0.0001789291,0.0005080963,0.01934104],"study_design_scores_gemma":[0.5478737,0.3016423,0.1414329,0.00009734988,0.001350081,0.000756591,0.00009005881,0.002100323,0.001625238,0.0004404896,0.002553423,0.00003768526],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965338,0.001301386,0.0003932963,0.0001280273,0.00004317132,0.0009546175,0.0002289826,0.00001366024,0.0004032258],"genre_scores_gemma":[0.9957837,0.0003625938,0.0008595007,0.0002915151,0.0001011581,0.001765525,0.0005653756,0.000005825181,0.0002649119],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004844074,"threshold_uncertainty_score":0.0256182,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06619436991627287,"score_gpt":0.3130700668664383,"score_spread":0.2468756969501654,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}