{"id":"W1563246140","doi":"10.1002/0471142700.nc1603s39","title":"Chemical Modification of siRNA","year":2009,"lang":"en","type":"review","venue":"Current Protocols in Nucleic Acid Chemistry","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":83,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Natural Sciences and Engineering Research Council of Canada; Novartis Institutes for BioMedical Research","keywords":"Small interfering RNA; RNA interference; Nucleic acid; Nuclease; RNA; Gene silencing; Trans-acting siRNA; Computational biology; Biology; Chemistry; Cell biology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003669889,0.001010364,0.0007107476,0.0007755051,0.0002970831,0.000379888,0.0009308685,0.0009214753,0.002984538],"category_scores_gemma":[0.0003058401,0.0003233286,0.0004645762,0.000628333,0.0003427756,0.0005668141,0.000425224,0.0011477,0.00528032],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005226489,"about_ca_system_score_gemma":0.0003694188,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004347304,"about_ca_topic_score_gemma":0.0005846725,"domain_scores_codex":[0.9996399,0.00005720435,0.0000327625,0.00007958779,0.0001559935,0.00003457959],"domain_scores_gemma":[0.9999062,0.00002760885,0.00002174936,0.00001215246,0.00002500788,0.000007273586],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005361793,0.00008635717,0.0001382241,0.006945299,0.00006770273,0.0008759671,0.00008298237,0.0009763503,0.6065149,0.01186213,0.01253088,0.3598656],"study_design_scores_gemma":[0.00001640353,0.0001963958,0.000421947,0.0002200736,0.00003638346,0.002363833,0.00001687681,0.0004289344,0.4496682,0.001204762,0.5453914,0.0000347945],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.02026434,0.7729286,0.09853425,0.00139791,0.004041404,0.0008944175,0.0006760775,0.001020503,0.1002425],"genre_scores_gemma":[0.109546,0.7499372,0.06959448,0.002142874,0.0007850082,0.001010511,0.001239353,0.0001583942,0.06558631],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002984538,"threshold_uncertainty_score":0.009984255,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07020345743764761,"score_gpt":0.3930853562615969,"score_spread":0.3228818988239492,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}