{"id":"W1563246140","doi":"10.1002/0471142700.nc1603s39","title":"Chemical Modification of siRNA","year":2009,"lang":"en","type":"review","venue":"Current Protocols in Nucleic Acid Chemistry","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":83,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Natural Sciences and Engineering Research Council of Canada; Novartis Institutes for BioMedical Research","keywords":"Small interfering RNA; RNA interference; Nucleic acid; Nuclease; RNA; Gene silencing; Trans-acting siRNA; Computational biology; Biology; Chemistry; Cell biology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001654681,0.0004727755,0.0009858466,0.00005293642,0.00001990497,0.00002318995,0.0008730502,0.0006789173,0.0000520754],"category_scores_gemma":[0.000104205,0.0004465821,0.0004597451,0.0001859352,0.0001180622,0.000005487309,0.0001969908,0.0004764055,0.00002076436],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007217848,"about_ca_system_score_gemma":0.0003073048,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":6.685237e-7,"about_ca_topic_score_gemma":1.463721e-7,"domain_scores_codex":[0.9977638,0.00005120354,0.0009370264,0.0007095045,0.0002134714,0.0003249752],"domain_scores_gemma":[0.9983237,0.000009587331,0.000569587,0.0009039709,0.0001000358,0.00009312354],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00003086362,0.0003033521,0.000005330956,0.01437685,0.00003580065,0.000001662866,0.00000789499,7.524683e-7,0.1320677,0.000005019167,0.001176496,0.8519883],"study_design_scores_gemma":[0.0002948517,0.00005023711,9.425913e-7,0.01023991,0.0000581403,0.00001592799,0.000003820056,0.000005090248,0.2168531,0.00003022009,0.7720379,0.0004098936],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0008167496,0.9832412,0.00004287215,0.000003927993,0.00006402565,0.01462009,0.0000666417,0.00001668729,0.001127808],"genre_scores_gemma":[0.000526776,0.9746698,0.0001204479,0.00000761189,0.0004150051,0.02329667,0.0007897776,0.00005162389,0.0001223003],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8515784,"threshold_uncertainty_score":0.9997986,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07020345743764761,"score_gpt":0.3930853562615969,"score_spread":0.3228818988239492,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}