{"id":"W1563683377","doi":"10.1046/j.1471-4159.2001.00005.x","title":"The palmitoylation state of the β<sub>2</sub>‐adrenergic receptor regulates the synergistic action of cyclic AMP‐dependent protein kinase and β‐adrenergic receptor kinase involved in its phosphorylation and desensitization","year":2001,"lang":"en","type":"article","venue":"Journal of Neurochemistry","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":59,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Medical Research Council Canada; Heart and Stroke Foundation of Canada","keywords":"Homologous desensitization; Beta adrenergic receptor kinase; Phosphorylation; Desensitization (medicine); Agonist; Palmitoylation; Protein kinase A; Receptor; Biology; Chemistry; Kinase; Endocrinology; Biochemistry; G protein-coupled receptor; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004789663,0.0001649214,0.0001863354,0.0000409488,0.0001450719,0.00003733975,0.0001636729,0.000119222,0.000004039549],"category_scores_gemma":[0.000363295,0.0001032358,0.00008358192,0.0001864656,0.0001136067,0.0000200592,0.00007173686,0.0002032354,1.766244e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002991409,"about_ca_system_score_gemma":0.00007276496,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008982268,"about_ca_topic_score_gemma":0.00003180787,"domain_scores_codex":[0.9986033,0.0001849337,0.0005681506,0.0001988836,0.000287266,0.0001574146],"domain_scores_gemma":[0.9985455,0.00007031613,0.0008214466,0.000225225,0.0002781047,0.00005938398],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003555611,0.00003903941,0.0004667503,0.00005071509,0.00002635202,0.000001840865,0.00006403218,0.002138421,0.9931195,0.00001136338,0.00002171948,0.003704719],"study_design_scores_gemma":[0.0004881977,0.000131059,0.003541416,0.0001395725,0.00002921577,0.00003036862,0.0001375423,0.0004715144,0.9945878,0.0002027659,0.0001385236,0.0001019709],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997773,0.001473871,0.0002124016,0.0001645433,0.0001587739,0.0001980919,0.000006547649,0.000002710409,0.00001008102],"genre_scores_gemma":[0.9967654,0.002913594,0.00006043086,0.00001925686,0.0001319783,0.000007387209,0.00001641367,0.00001914358,0.00006638341],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003602748,"threshold_uncertainty_score":0.4209836,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0115362257552927,"score_gpt":0.2215096713145774,"score_spread":0.2099734455592847,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}