{"id":"W1563718990","doi":"10.1016/s1525-0016(03)00192-8","title":"Nonclinical Toxicology in Support of Licensure of Gene Therapies","year":2003,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Licensure; Medicine; Clinical trial; Pharmacology; Medical education; Pathology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007158362,0.0001786596,0.0003406202,0.00011341,0.00001838591,0.000004484577,0.0003099976,0.0002567801,0.0002160681],"category_scores_gemma":[0.0000820759,0.0001675558,0.0001836534,0.0002182818,0.0002166331,0.000002360775,0.00002944526,0.0001406086,0.000006131052],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001043378,"about_ca_system_score_gemma":0.0002037438,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001042444,"about_ca_topic_score_gemma":0.00005087562,"domain_scores_codex":[0.9982016,0.0004585791,0.0004449509,0.0003444919,0.0002312184,0.0003191574],"domain_scores_gemma":[0.9990385,0.00003088227,0.0001309487,0.0006002362,0.000132876,0.00006651557],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001633963,0.0003772108,0.004093308,0.000009462914,0.0001408445,0.00001543911,0.0001098148,0.00008920406,0.9903229,0.00018271,0.0001207188,0.002904367],"study_design_scores_gemma":[0.00207776,0.004938141,0.001186219,0.000003760151,0.000004105474,0.000009277356,0.0000307582,0.00000256406,0.9784065,0.0002187976,0.01297052,0.0001515255],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940023,0.004071212,0.0004022759,0.0001878605,0.00006072519,0.0002859972,0.00001464974,0.000005198622,0.000969729],"genre_scores_gemma":[0.9965777,0.001399895,0.0009222662,0.0008233803,0.00002753332,0.00002999114,0.00002927132,0.00004048738,0.0001494162],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0128498,"threshold_uncertainty_score":0.6832729,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02525211919586532,"score_gpt":0.3332416326986046,"score_spread":0.3079895135027393,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}