{"id":"W1563718990","doi":"10.1016/s1525-0016(03)00192-8","title":"Nonclinical Toxicology in Support of Licensure of Gene Therapies","year":2003,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Licensure; Medicine; Clinical trial; Pharmacology; Medical education; Pathology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.08513527,0.000942123,0.000879243,0.001871308,0.006868834,0.0110828,0.005018835,0.0180153,0.02304783],"category_scores_gemma":[0.09452995,0.001035688,0.001619151,0.000802849,0.00531315,0.006604937,0.007249293,0.0148233,0.009850163],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.005453926,"about_ca_system_score_gemma":0.03363904,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003800008,"about_ca_topic_score_gemma":0.007684597,"domain_scores_codex":[0.9233756,0.02831296,0.006090987,0.003964696,0.03402121,0.004234542],"domain_scores_gemma":[0.8613182,0.05603163,0.01158164,0.008599638,0.05329679,0.00917202],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003698148,0.0007837133,0.004414801,0.001106963,0.00003876931,0.003097309,0.005671075,0.0004391766,0.0232332,0.06644415,0.5797633,0.3146378],"study_design_scores_gemma":[0.00006135499,0.0005516312,0.00225185,0.0006605523,0.00001770459,0.00117437,0.001137922,0.0003205446,0.006233578,0.006692489,0.9808344,0.00006357151],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"methods","genre_scores_codex":[0.01818346,0.02270661,0.04304652,0.5822469,0.03223017,0.002528311,0.0003390159,0.001567704,0.2971513],"genre_scores_gemma":[0.2088821,0.0251684,0.0407556,0.3901796,0.01632238,0.00209511,0.001223995,0.001097648,0.3142752],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.08513527,"threshold_uncertainty_score":0.4502437,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02525211919586532,"score_gpt":0.3332416326986046,"score_spread":0.3079895135027393,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}