{"id":"W156410711","doi":"10.1007/8904_2014_350","title":"Early Umbilical Cord Blood-Derived Stem Cell Transplantation Does Not Prevent Neurological Deterioration in Mucopolysaccharidosis Type III","year":2014,"lang":"en","type":"article","venue":"JIMD Reports","topic":"Lysosomal Storage Disorders Research","field":"Medicine","cited_by":48,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institute of Neurological Disorders and Stroke; Canadian Institutes of Health Research; National Institutes of Health; Biomedical Research Council; National University of Singapore; Rare Disease Foundation; Japan Society for the Promotion of Science; National Center for Research Resources; Georgia Clinical and Translational Science Alliance; Sanofi; State Government of Victoria; Ministero della Salute; BioMarin Pharmaceutical; Amgen","keywords":"Mucopolysaccharidosis; Medicine; Hematopoietic stem cell transplantation; Transplantation; Umbilical cord; Lysosomal storage disease; Mucopolysaccharidosis type I; Stem cell; Immunology; Internal medicine; Haematopoiesis; Enzyme replacement therapy; Disease; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002345785,0.0002876823,0.0008507342,0.0002088479,0.0001537829,0.0002789919,0.0003701499,0.0003881033,0.001711231],"category_scores_gemma":[0.0003263465,0.00007937536,0.0002318281,0.0001824759,0.0003842315,0.0002363383,0.0001256981,0.000873587,0.000288912],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001160488,"about_ca_system_score_gemma":0.0003358052,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005614552,"about_ca_topic_score_gemma":0.0007910667,"domain_scores_codex":[0.9999352,0.0000123485,0.000007774393,0.00001035309,0.0000133669,0.00002107864],"domain_scores_gemma":[0.9997754,0.00007489313,0.00003014256,0.00003737184,0.00001417707,0.00006802916],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.03173467,0.006057568,0.005101093,0.0005196591,0.000250987,0.00281872,0.0001067876,0.000703535,0.8281089,0.0008581374,0.002132002,0.121608],"study_design_scores_gemma":[0.005171027,0.0553514,0.09920431,0.0002694433,0.0009014953,0.008626068,0.0003031507,0.00310176,0.8146418,0.001738294,0.01063603,0.00005521259],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949122,0.002843178,0.0005836725,0.0001122749,0.0001251146,0.00002081239,0.0001458426,0.00008504092,0.001171953],"genre_scores_gemma":[0.9970024,0.001211164,0.0003041223,0.0001123302,0.00003785579,0.00001605994,0.0003488647,0.00001310909,0.0009539732],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001711231,"threshold_uncertainty_score":0.005724609,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01955916357473064,"score_gpt":0.2762605713292396,"score_spread":0.256701407754509,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}