{"id":"W156410711","doi":"10.1007/8904_2014_350","title":"Early Umbilical Cord Blood-Derived Stem Cell Transplantation Does Not Prevent Neurological Deterioration in Mucopolysaccharidosis Type III","year":2014,"lang":"en","type":"article","venue":"JIMD Reports","topic":"Lysosomal Storage Disorders Research","field":"Medicine","cited_by":48,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institute of Neurological Disorders and Stroke; Canadian Institutes of Health Research; National Institutes of Health; Biomedical Research Council; National University of Singapore; Rare Disease Foundation; Japan Society for the Promotion of Science; National Center for Research Resources; Georgia Clinical and Translational Science Alliance; Sanofi; State Government of Victoria; Ministero della Salute; BioMarin Pharmaceutical; Amgen","keywords":"Mucopolysaccharidosis; Medicine; Hematopoietic stem cell transplantation; Transplantation; Umbilical cord; Lysosomal storage disease; Mucopolysaccharidosis type I; Stem cell; Immunology; Internal medicine; Haematopoiesis; Enzyme replacement therapy; Disease; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004594506,0.0001716012,0.0003479618,0.0001308376,0.00006292924,0.00003868897,0.00007532236,0.0001948071,0.0001445245],"category_scores_gemma":[0.00009684102,0.0001250074,0.00009283001,0.0002525289,0.0000581299,0.0001174399,0.00003446141,0.0003187473,0.00002028214],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003970894,"about_ca_system_score_gemma":0.00008354151,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000323588,"about_ca_topic_score_gemma":0.0001312403,"domain_scores_codex":[0.9978349,0.000185178,0.0005898025,0.0005251603,0.0005405938,0.0003243548],"domain_scores_gemma":[0.9990827,0.00008438284,0.0001723525,0.0003676295,0.0001246464,0.0001682608],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.002091271,0.000981454,0.2517322,0.00025211,0.00003157834,0.003573596,0.0008201771,0.00001151029,0.727963,0.00001952424,0.0000421258,0.01248138],"study_design_scores_gemma":[0.002206665,0.002928154,0.8157548,0.00006898034,0.0001733087,0.0007858212,0.00005894445,0.000699586,0.1766677,0.0001654203,0.0001985238,0.0002920742],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977585,0.00004242883,0.0002402356,0.0004819647,0.0002455081,0.0007409379,0.000001621998,0.00008303937,0.0004057845],"genre_scores_gemma":[0.9987378,0.00007482304,0.0001614278,0.0002553052,0.00008886563,0.00006337956,0.0000278059,0.00002563919,0.0005649331],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5640227,"threshold_uncertainty_score":0.5097653,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01955916357473064,"score_gpt":0.2762605713292396,"score_spread":0.256701407754509,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}