{"id":"W1564158892","doi":"10.1038/jcbfm.2015.133","title":"Blocking of Fatty Acid Amide Hydrolase Activity with PF-04457845 in Human Brain: A Positron Emission Tomography Study with the Novel Radioligand [ <sup>11</sup> C]CURB","year":2015,"lang":"en","type":"article","venue":"Journal of Cerebral Blood Flow & Metabolism","topic":"Cannabis and Cannabinoid Research","field":"Medicine","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Centre for Addiction and Mental Health","funders":"Ontario Ministry of Research and Innovation; Pfizer","keywords":"Fatty acid amide hydrolase; Radioligand; Positron emission tomography; Anandamide; Intraclass correlation; In vivo; Human brain; Endocannabinoid system; Standardized uptake value; Radiosynthesis; Pharmacology; Nuclear medicine; Chemistry; Medicine; Internal medicine; Reproducibility; Biochemistry; Antagonist; Cannabinoid receptor; Biology; Chromatography; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000465554,0.0003853582,0.0005025381,0.0001457958,0.0002347901,0.0003174888,0.0003512803,0.0004810553,0.0006693157],"category_scores_gemma":[0.0006857697,0.0004012056,0.0002026499,0.0001647038,0.000729462,0.0002543627,0.0001318037,0.0005555464,0.0002865602],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000463009,"about_ca_system_score_gemma":0.0002550166,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004965684,"about_ca_topic_score_gemma":0.003324233,"domain_scores_codex":[0.9997851,0.00008246091,0.000007763712,0.00006698348,0.00002944887,0.00002825064],"domain_scores_gemma":[0.9998176,0.00005003348,0.00004892874,0.00004074301,0.00002235021,0.00002035839],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.01120279,0.0009391677,0.01575489,0.0001897765,0.000393725,0.0009481997,0.0005594637,0.000925148,0.9492861,0.0001477236,0.0002799334,0.0193731],"study_design_scores_gemma":[0.001247812,0.04600609,0.419439,0.00002459516,0.001076317,0.01342778,0.0006601805,0.01094109,0.5020586,0.0004375709,0.004573918,0.0001071151],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977355,0.0008101044,0.001158941,0.0000290406,0.000004256047,0.0000216302,0.00004189246,0.00001145522,0.0001872423],"genre_scores_gemma":[0.9982546,0.0005113649,0.000689654,0.00004906984,0.000007842322,0.00003351057,0.0001494393,0.000009656051,0.0002949401],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004965684,"threshold_uncertainty_score":0.009873569,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01482654433002138,"score_gpt":0.2710731777805893,"score_spread":0.2562466334505679,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}