{"id":"W1564764260","doi":"10.1161/circ.130.suppl_2.15546","title":"Abstract 15546: Loss of Mitochondrial UCP3-Cytochrome c Oxidase Complexes Underlies Maladaptive Autophagy and Cardiac Failure in Anthracycline Cardiotoxicity","year":2014,"lang":"en","type":"article","venue":"Circulation","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Boniface Hospital","funders":"","keywords":"UCP3; Autophagy; Doxorubicin; Cardiotoxicity; Mitochondrion; Programmed cell death; Medicine; Respiratory chain; Cytochrome c oxidase; Mitochondrial respiratory chain; Cell biology; Biology; Pharmacology; Cancer research; Apoptosis; Internal medicine; Uncoupling protein; Biochemistry; Toxicity; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001652732,0.0004697265,0.0003672137,0.000253112,0.0001924463,0.0002227436,0.0002409618,0.0004738532,0.004980247],"category_scores_gemma":[0.00008795576,0.0001592404,0.0002144579,0.0001547842,0.0003729056,0.0002221508,0.0002879765,0.0006656104,0.001261878],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002151791,"about_ca_system_score_gemma":0.0001306587,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000246265,"about_ca_topic_score_gemma":0.0001985477,"domain_scores_codex":[0.9999157,0.00001285151,0.00001333001,0.00002381163,0.00001801849,0.00001629713],"domain_scores_gemma":[0.9999024,0.000008747019,0.00003839377,0.000007826388,0.000007967062,0.00003465278],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0006568396,0.00005120238,0.0007747844,0.0001103109,0.00001304484,0.0009636399,0.00002160223,0.00002964825,0.9951841,0.0001642409,0.0002543119,0.001776091],"study_design_scores_gemma":[0.0001911596,0.001425725,0.05139386,0.00006228137,0.0000864993,0.01556678,0.00008038268,0.00091703,0.9205416,0.0003721901,0.009347566,0.00001490693],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9867876,0.003803376,0.004216483,0.0006378154,0.0001894629,0.00008219857,0.001222059,0.0001792711,0.002881697],"genre_scores_gemma":[0.9874812,0.00219222,0.001361741,0.0001925085,0.00009213731,0.00008497451,0.001163965,0.00004336987,0.007387936],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004980247,"threshold_uncertainty_score":0.01666057,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01203868580022024,"score_gpt":0.2469585477137219,"score_spread":0.2349198619135017,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}