{"id":"W1566211063","doi":"10.1111/j.1474-9726.2010.00571.x","title":"Two modes of mitochondrial dysfunction lead independently to lifespan extension in <i>Caenorhabditis elegans</i>","year":2010,"lang":"en","type":"article","venue":"Aging Cell","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":257,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research","keywords":"Biology; RNA interference; Caenorhabditis elegans; Mutant; Phenotype; Mutation; Genetics; Mitochondrion; Gene; Reactive oxygen species; Cell biology; Longevity; RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001707195,0.0005255886,0.0002247536,0.000297664,0.0002554703,0.0002774362,0.0003807006,0.0004660075,0.0006955208],"category_scores_gemma":[0.0001878291,0.0002494579,0.0004220597,0.0001039269,0.0003195007,0.0002316332,0.0003779345,0.0007297891,0.0002419572],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005044631,"about_ca_system_score_gemma":0.0002280105,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001492628,"about_ca_topic_score_gemma":0.003601638,"domain_scores_codex":[0.9998234,0.0000139523,0.00003753981,0.00005514265,0.00003535213,0.00003460276],"domain_scores_gemma":[0.999668,0.0000342928,0.0001220962,0.00003750177,0.00003041247,0.0001076866],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001604733,0.00003655369,0.0005619549,0.0000314777,0.000006532892,0.0001274369,0.00001189712,0.00005883058,0.9982457,0.00006442331,0.00005945649,0.0006352004],"study_design_scores_gemma":[0.00007009407,0.00049744,0.03681382,0.00002614066,0.00003987032,0.0008784303,0.00006212603,0.001746891,0.9585487,0.0001212799,0.001166516,0.00002869205],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967977,0.0003473248,0.001122446,0.00008109303,0.00002531003,0.00002399903,0.0005421595,0.0001340326,0.0009259119],"genre_scores_gemma":[0.9956214,0.0002170025,0.001677001,0.000164836,0.000006699157,0.00005919491,0.0005913229,0.00005394474,0.001608645],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001492628,"threshold_uncertainty_score":0.003660142,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006057740048702825,"score_gpt":0.2284798480885181,"score_spread":0.2224221080398153,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}