{"id":"W1566211063","doi":"10.1111/j.1474-9726.2010.00571.x","title":"Two modes of mitochondrial dysfunction lead independently to lifespan extension in <i>Caenorhabditis elegans</i>","year":2010,"lang":"en","type":"article","venue":"Aging Cell","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":257,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research","keywords":"Biology; RNA interference; Caenorhabditis elegans; Mutant; Phenotype; Mutation; Genetics; Mitochondrion; Gene; Reactive oxygen species; Cell biology; Longevity; RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001384471,0.0001775487,0.0001820089,0.0001085167,0.000052261,0.00002605151,0.0002279828,0.0001640068,0.00002241369],"category_scores_gemma":[0.00005048436,0.0001933475,0.00007159827,0.0001079554,0.00005018606,0.000007257621,0.0001262164,0.0002346966,0.00002302609],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001067092,"about_ca_system_score_gemma":0.00006091175,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004726776,"about_ca_topic_score_gemma":0.001797544,"domain_scores_codex":[0.998755,0.00004600053,0.0002703608,0.0004419102,0.0001946039,0.0002920653],"domain_scores_gemma":[0.9992279,0.00001232857,0.00008883166,0.0004726781,0.00009990029,0.0000983306],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004228975,0.00009126313,0.004693175,0.00002217937,0.000007074666,0.000004250266,0.000320261,0.001074445,0.992066,0.00001781425,0.0005239277,0.001137375],"study_design_scores_gemma":[0.000922922,0.0001776825,0.004126023,0.00001683572,0.00001465753,0.000009772035,0.00009113704,0.0003341874,0.9910499,0.0001040647,0.002922555,0.0002301947],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9907804,0.000123118,0.006868079,0.0001182141,0.0009698118,0.0002098565,0.0000112932,0.00001610184,0.0009031591],"genre_scores_gemma":[0.9926036,0.00004364482,0.005697937,0.0003840415,0.0005432114,0.000008948085,0.00004059942,0.000036258,0.0006417524],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002398628,"threshold_uncertainty_score":0.7884484,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006057740048702825,"score_gpt":0.2284798480885181,"score_spread":0.2224221080398153,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}