{"id":"W1566601068","doi":"10.1124/jpet.115.226092","title":"Sildenafil Does Not Prevent Heart Hypertrophy and Fibrosis Induced by Cardiomyocyte Angiotensin II Type 1 Receptor Signaling","year":2015,"lang":"en","type":"article","venue":"Journal of Pharmacology and Experimental Therapeutics","topic":"Heart Failure Treatment and Management","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":false,"ca_institutions":"Montreal Clinical Research Institute; University of Ottawa","funders":"","keywords":"Sildenafil; Angiotensin II; Internal medicine; Endocrinology; Renin–angiotensin system; Medicine; Fibrosis; Muscle hypertrophy; Cardiac hypertrophy; Receptor; Pharmacology; Angiotensin II receptor type 1; Blood pressure","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000282723,0.0003666895,0.0008963032,0.0001844464,0.0003034241,0.0005469382,0.0004125043,0.0005442535,0.003715168],"category_scores_gemma":[0.0004008556,0.0002785138,0.0005019526,0.000111671,0.0003786727,0.0005492849,0.0002397669,0.001666473,0.0007325808],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002057181,"about_ca_system_score_gemma":0.0005790992,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007049197,"about_ca_topic_score_gemma":0.002546459,"domain_scores_codex":[0.9997959,0.0000357679,0.00002206454,0.0000272555,0.00004391876,0.00007525882],"domain_scores_gemma":[0.9996409,0.00007519822,0.00007144042,0.00004781093,0.00002652715,0.000137984],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01937988,0.002159666,0.003979535,0.0006945974,0.0003811167,0.0006621312,0.0001928051,0.0003153752,0.916836,0.000948493,0.003635089,0.05081531],"study_design_scores_gemma":[0.007153968,0.02496613,0.1121374,0.0001599645,0.001619864,0.001293791,0.0005711631,0.006167529,0.8157997,0.0006519643,0.0293856,0.00009288387],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.985292,0.006273462,0.001018543,0.0009588199,0.0008706326,0.00005116308,0.0004831783,0.000249944,0.00480246],"genre_scores_gemma":[0.9917352,0.002700762,0.0006611065,0.0004226027,0.000320512,0.00004517473,0.0006755797,0.00002241128,0.003416699],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003715168,"threshold_uncertainty_score":0.01242846,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04224051813724564,"score_gpt":0.3352817955884709,"score_spread":0.2930412774512253,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}