{"id":"W156668974","doi":"10.1021/bi101432p","title":"Improving a Designed Photocontrolled DNA-Binding Protein","year":2011,"lang":"en","type":"article","venue":"Biochemistry","topic":"Photoreceptor and optogenetics research","field":"Neuroscience","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University of Waterloo","funders":"National Institute of Mental Health; Canadian Institutes of Health Research","keywords":"Cooperativity; DNA; Chemistry; Biophysics; Cooperative binding; Mutant; Denaturation (fissile materials); Point mutation; Fusion protein; DNA-binding protein; Crystallography; Transcription factor; Biochemistry; Binding site; Biology; Gene; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001900956,0.0001571492,0.0001435416,0.00004958119,0.0001512067,0.00005559973,0.0004561911,0.0001143625,0.0007163936],"category_scores_gemma":[0.0006527578,0.0001460531,0.00008377617,0.0001940929,0.0001144576,0.00005588628,0.000123899,0.0001632714,0.000123245],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006567943,"about_ca_system_score_gemma":0.0001232146,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001991923,"about_ca_topic_score_gemma":5.059379e-7,"domain_scores_codex":[0.9985574,0.00005104113,0.0001848673,0.0004539923,0.0003077537,0.00044494],"domain_scores_gemma":[0.9993135,0.00004350271,0.0000759362,0.000348144,0.00003622163,0.0001826336],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001419974,0.00006942535,0.00006046559,0.00003608287,0.000003134358,0.00001952049,0.00007485477,2.217899e-8,0.9988294,0.00001845504,0.00005155242,0.0006951538],"study_design_scores_gemma":[0.0007564055,0.00004996456,0.00001097234,0.00001507436,0.000003772767,0.000008489841,0.00003076856,0.0001835935,0.998638,0.00004404942,0.00008064325,0.0001782946],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9818714,0.00001496838,0.0001253595,0.000008211944,0.00004607721,0.0007767044,0.00001351495,0.00009043334,0.01705331],"genre_scores_gemma":[0.9952998,0.000002364767,0.0008397926,0.00003634728,0.00006960852,0.0003951844,0.000002046842,0.00002488073,0.003330034],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01372327,"threshold_uncertainty_score":0.7844008,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05504466399190645,"score_gpt":0.2786538816525998,"score_spread":0.2236092176606934,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}