{"id":"W1567441236","doi":"10.1016/s0074-7742(07)79007-4","title":"Molecular “Negativity” May Underlie Multiple Sclerosis: Role of the Myelin Basic Protein Family in the Pathogenesis of MS","year":2007,"lang":"en","type":"review","venue":"International review of neurobiology","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":54,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Guelph","funders":"","keywords":"Citrullination; Myelin basic protein; Myelin; Multiple sclerosis; Pathogenesis; Proteolipid protein 1; Oligodendrocyte; Neuromyelitis optica; Neurodegeneration; Epitope; Neuroscience; Biology; Cell biology; Immunology; Chemistry; Central nervous system; Medicine; Antigen; Disease; Citrulline; Pathology; Genetics; Amino acid","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005554924,0.0008510622,0.001539776,0.001312634,0.0002382783,0.0008602573,0.001149463,0.001217759,0.001808076],"category_scores_gemma":[0.0006688958,0.000181187,0.0003707319,0.001765243,0.0006682204,0.001163245,0.0006256453,0.001273358,0.001088169],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005527317,"about_ca_system_score_gemma":0.001042156,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001018511,"about_ca_topic_score_gemma":0.001460189,"domain_scores_codex":[0.9998664,0.00002801381,0.00002031101,0.0000280211,0.00004581791,0.00001160181],"domain_scores_gemma":[0.9997167,0.0001406873,0.00005214363,0.000007315501,0.00006577789,0.00001727366],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001589316,0.0000619545,0.0005540465,0.02010725,0.0002000303,0.0008707527,0.0000905686,0.0003711231,0.00447959,0.00691832,0.02837695,0.9378104],"study_design_scores_gemma":[0.00004408099,0.0001005703,0.002726892,0.00422251,0.0003231397,0.006825777,0.0001727441,0.0001437013,0.001112004,0.00796407,0.9763201,0.00004427708],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001138141,0.9990434,0.000123379,0.0002242503,0.0001234176,0.000002253088,0.000007426244,0.000003656624,0.0003583427],"genre_scores_gemma":[0.0007403524,0.9985979,0.0001527345,0.0001506655,0.0001499625,0.000002839937,0.00001195554,6.187639e-7,0.0001929711],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001808076,"threshold_uncertainty_score":0.00604862,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1356804866832504,"score_gpt":0.3808776089235395,"score_spread":0.2451971222402891,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}