{"id":"W1567682956","doi":"10.1111/cbdd.12060","title":"Chemotherapy Drugs Form Ion Pores in Membranes Due to Physical Interactions with Lipids","year":2012,"lang":"en","type":"article","venue":"Chemical Biology & Drug Design","topic":"Lipid Membrane Structure and Behavior","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Membrane; van der Waals force; Lipid bilayer; Molecular dynamics; POPC; Biophysics; Chemistry; Ion channel; Conductance; Drug; Molecular mechanics; Ion; Cell membrane; Chemical physics; Computational chemistry; Biochemistry; Molecule; Pharmacology; Organic chemistry; Receptor; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006415604,0.0001972933,0.0001752018,0.0001156769,0.0002435364,0.0002448047,0.0001706248,0.0002705452,0.0007410478],"category_scores_gemma":[0.0001514719,0.0001104934,0.0001868445,0.00008899484,0.0003666829,0.000366788,0.000307683,0.0002827866,0.0001922781],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002039247,"about_ca_system_score_gemma":0.0001210858,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003518582,"about_ca_topic_score_gemma":0.0003022559,"domain_scores_codex":[0.9999354,0.00001078139,0.000002911342,0.00001119573,0.00002346328,0.00001627049],"domain_scores_gemma":[0.9999275,0.00002487991,0.00002413274,0.000006025412,0.000008901883,0.000008593855],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004597373,0.00001416988,0.0005434398,0.00003812938,0.00000823229,0.0002246421,0.00002406235,0.00129652,0.9956473,0.000791589,0.00003745588,0.001328586],"study_design_scores_gemma":[0.00002478056,0.0001537439,0.002069209,0.000004972318,0.00001279531,0.0004319436,0.00004379065,0.009326004,0.9860485,0.0004636001,0.001414217,0.000006468325],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9906794,0.0008246293,0.006153439,0.0001621418,0.00001585145,0.00001601818,0.00004620092,0.00007179677,0.00203052],"genre_scores_gemma":[0.997328,0.000500408,0.001750188,0.00003565927,0.000003119967,0.00001055908,0.00002950666,0.000005098909,0.0003374436],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007410478,"threshold_uncertainty_score":0.002479017,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009798058275809835,"score_gpt":0.2670100940259524,"score_spread":0.2572120357501426,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}