{"id":"W1567682956","doi":"10.1111/cbdd.12060","title":"Chemotherapy Drugs Form Ion Pores in Membranes Due to Physical Interactions with Lipids","year":2012,"lang":"en","type":"article","venue":"Chemical Biology & Drug Design","topic":"Lipid Membrane Structure and Behavior","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Membrane; van der Waals force; Lipid bilayer; Molecular dynamics; POPC; Biophysics; Chemistry; Ion channel; Conductance; Drug; Molecular mechanics; Ion; Cell membrane; Chemical physics; Computational chemistry; Biochemistry; Molecule; Pharmacology; Organic chemistry; Receptor; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001494371,0.0002614691,0.0002986375,0.00006846972,0.00004455055,0.00001167189,0.000226809,0.0001745769,0.00003904117],"category_scores_gemma":[0.00003329088,0.0001916159,0.00009296277,0.0001640714,0.00013836,0.00001366812,0.00006899281,0.0002004277,0.00002420562],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003017037,"about_ca_system_score_gemma":0.00004377931,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001960407,"about_ca_topic_score_gemma":0.000006909913,"domain_scores_codex":[0.9987569,0.00007130695,0.0001975422,0.0004009723,0.00007804007,0.0004952573],"domain_scores_gemma":[0.9993474,0.00005643347,0.00005680319,0.0003085937,0.00004242791,0.0001882987],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004139735,0.0002045765,0.001669184,0.00001171362,0.00003137785,0.000001297021,0.0005861134,0.000003688401,0.991861,0.00004336201,0.0008235447,0.004350158],"study_design_scores_gemma":[0.0008004753,0.0001360917,0.0005998569,0.00001426892,0.00002487086,0.00004350936,0.0001072406,0.000005868722,0.9844065,0.00006295135,0.01352398,0.0002744079],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978105,0.00008374053,0.0005806023,0.0005136426,0.0002494263,0.0003226648,0.000009630835,0.00002806652,0.0004016753],"genre_scores_gemma":[0.9960161,0.0000207896,0.001314657,0.0008191536,0.001343319,0.0001058541,0.000132779,0.00003196549,0.000215411],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01270043,"threshold_uncertainty_score":0.7813868,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009798058275809835,"score_gpt":0.2670100940259524,"score_spread":0.2572120357501426,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}