{"id":"W1567698310","doi":"10.1161/circulationaha.114.013729","title":"Response to Letter Regarding Article, “Proprotein Convertase Subtilisin Kexin Type 9 Promotes Intestinal Overproduction of Triglyceride-Rich Apolipoprotein B Lipoproteins Through Both Low-Density Lipoprotein Receptor–Dependent and –Independent Mechanisms”","year":2015,"lang":"en","type":"letter","venue":"Circulation","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Cancer Care Ontario; University of Toronto; Dalhousie University","funders":"National Heart, Lung, and Blood Institute","keywords":"Kexin; Proprotein convertase; Medicine; Subtilisin; Apolipoprotein B; PCSK9; Overproduction; Triglyceride; Internal medicine; Endocrinology; Lipoprotein; LDL receptor; Biochemistry; Cholesterol; Enzyme; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002135699,0.0009958508,0.001570001,0.0008030254,0.003068932,0.003238057,0.001530861,0.0357719,0.00589044],"category_scores_gemma":[0.01846037,0.0007541469,0.001418338,0.0004976559,0.001636932,0.00227674,0.001190972,0.02759285,0.005880297],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003458773,"about_ca_system_score_gemma":0.002914025,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004212374,"about_ca_topic_score_gemma":0.00743336,"domain_scores_codex":[0.9981441,0.0004787209,0.0002416639,0.0002912947,0.0005046035,0.0003395468],"domain_scores_gemma":[0.9966793,0.001573565,0.000339108,0.0001065083,0.0007649099,0.0005365778],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000122074,0.0000797722,0.0009085712,0.00004926241,0.00003085996,0.002337673,0.00007191343,0.00006063774,0.0002092765,0.0007686924,0.9910199,0.004341266],"study_design_scores_gemma":[0.0004921986,0.0003496958,0.00558146,0.0004971647,0.0001393414,0.004506427,0.0006641936,0.001266604,0.0006885278,0.005768971,0.9798988,0.0001465651],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.0006705294,0.0008318553,0.0000948431,0.9536628,0.04265119,0.00002054636,0.0001145706,0.00004557649,0.001908021],"genre_scores_gemma":[0.004158846,0.0007147699,0.0001864541,0.9442081,0.04333265,0.00004396354,0.000086985,0.00002369189,0.00724458],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.0357719,"threshold_uncertainty_score":0.02509522,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02401001740347459,"score_gpt":0.2596004762532867,"score_spread":0.2355904588498122,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}