{"id":"W1568474022","doi":"10.1038/74101","title":"The NMR structure of the 38 kDa U1A protein - PIE RNA complex reveals the basis of cooperativity in regulation of polyadenylation by human U1A protein.","year":2000,"lang":"en","type":"article","venue":"Nature Structural Biology","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":136,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Medical Research Council","keywords":"Polyadenylation; RNA; RNA-binding protein; Cooperativity; Small nuclear RNA; Cooperative binding; Cell biology; Messenger RNA; Binding site; Biology; Chemistry; Biochemistry; Molecular biology; Non-coding RNA; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001236531,0.0002241527,0.0001496231,0.0001627403,0.0004611111,0.0003050449,0.0003565788,0.0003278936,0.001901306],"category_scores_gemma":[0.0003901203,0.0001875489,0.0001296324,0.0001653105,0.0003171433,0.00039126,0.0001920837,0.000545883,0.0003009955],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006241734,"about_ca_system_score_gemma":0.0001918165,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001730361,"about_ca_topic_score_gemma":0.002484985,"domain_scores_codex":[0.9999527,0.000005438055,0.000002005401,0.00001678787,0.00001135296,0.00001179639],"domain_scores_gemma":[0.9998437,0.00003232634,0.00004231723,0.00001550267,0.00001506819,0.00005107466],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004139312,0.00006061257,0.001765368,0.00006631845,0.00002129754,0.0004129624,0.0001491115,0.001649258,0.989872,0.001585199,0.0007069173,0.003297027],"study_design_scores_gemma":[0.0001823222,0.0006503247,0.1056826,0.00007066593,0.0001186872,0.002357854,0.0004457633,0.07865299,0.7862154,0.004925037,0.02055253,0.0001459232],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959045,0.000522821,0.001025607,0.0002977102,0.00001661361,0.000005017107,0.0001605573,0.0000590521,0.00200818],"genre_scores_gemma":[0.9960477,0.0002520506,0.002035042,0.00008925046,0.00001172297,0.00000747583,0.0005960393,0.00002211779,0.0009385487],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001901306,"threshold_uncertainty_score":0.006360471,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006819756538420233,"score_gpt":0.2804478375116952,"score_spread":0.273628080973275,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}