{"id":"W1568494879","doi":"10.1002/9780470513927.ch8","title":"Phospholipase C Isozymes: Structural and Functional Similarities","year":2007,"lang":"en","type":"article","venue":"Novartis Foundation symposium","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"Mount Sinai Hospital","funders":"","keywords":"Gene isoform; Isozyme; Phospholipase C; Tyrosine phosphorylation; Phosphorylation; Phosphatidylinositol; Biochemistry; Phospholipase; SH2 domain; Gq alpha subunit; Biology; Tyrosine; Cell biology; Chemistry; Enzyme; Signal transduction; Gene; G protein","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001531578,0.0005756875,0.0003124239,0.001027015,0.0003261916,0.001017957,0.0005047442,0.000592988,0.002816778],"category_scores_gemma":[0.0003388312,0.0001555285,0.000421272,0.0007976757,0.0002454467,0.0005730644,0.000434639,0.001364448,0.001996666],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004919809,"about_ca_system_score_gemma":0.0004165582,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005499822,"about_ca_topic_score_gemma":0.0002527794,"domain_scores_codex":[0.9998117,0.00001475955,0.00001599775,0.00003829565,0.0000775097,0.00004178915],"domain_scores_gemma":[0.999806,0.00001469219,0.00003715464,0.00001743803,0.00006989268,0.00005488325],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006478021,0.0002641296,0.003025823,0.0005391719,0.00004040142,0.002008303,0.0003526834,0.000388543,0.8874565,0.01447255,0.002403186,0.08840096],"study_design_scores_gemma":[0.0002407963,0.001280752,0.10767,0.0002764796,0.0001856315,0.0254267,0.0007141191,0.002467457,0.4028426,0.02525166,0.4335293,0.0001144705],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7554131,0.1006617,0.04942173,0.006035189,0.001308437,0.0005724938,0.003293312,0.0008936574,0.0824003],"genre_scores_gemma":[0.8465734,0.06946491,0.02595508,0.001862701,0.001116725,0.000494022,0.009489601,0.0001146388,0.04492879],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002816778,"threshold_uncertainty_score":0.009423018,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01350764579136756,"score_gpt":0.2558120957335792,"score_spread":0.2423044499422116,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}