{"id":"W1568585026","doi":"10.1186/ar1439","title":"Expression and regulation of microsomal prostaglandin E synthase-1 in human osteoarthritic cartilage and chondrocytes.","year":2004,"lang":"en","type":"article","venue":"Arthritis Research","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":85,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Hôpital Notre-Dame","funders":"Canadian Arthritis Network; School of Medicine, University of California, San Diego; Menzies Institute for Medical Research; National Cancer Institute; Arthritis Society; University of North Carolina at Chapel Hill; Genentech; National Institutes of Health; Biogen; Lupus Research Institute; Pfizer; Natural Sciences and Engineering Research Council of Canada; Dutch Arthritis Association; Oesterreichische Nationalbank; Deutsche Forschungsgemeinschaft; Nuffield Foundation; Physiotherapy Foundation of Canada; Canadian Institutes of Health Research; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Lupus Research Alliance; Wellcome Trust; Newcastle University; National Institute of Allergy and Infectious Diseases; Howard Hughes Medical Institute; Austrian Science Fund; Arthritis Foundation","keywords":"Western blot; Prostaglandin E2; Downregulation and upregulation; Chemistry; Messenger RNA; Molecular biology; Cartilage; Tumor necrosis factor alpha; Gene expression; Cyclooxygenase; Real-time polymerase chain reaction; Prostaglandin; Biology; Endocrinology; Enzyme; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000187163,0.0003087858,0.0002015014,0.0004983598,0.0001690445,0.0002696092,0.0001172803,0.0002720322,0.001267184],"category_scores_gemma":[0.0002562015,0.0001520694,0.0002354413,0.0003273442,0.0002370367,0.0001479002,0.0001600666,0.0002023686,0.0006430126],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003027043,"about_ca_system_score_gemma":0.000295632,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001249556,"about_ca_topic_score_gemma":0.001395917,"domain_scores_codex":[0.9997965,0.00002861122,0.00002051189,0.00004899415,0.00006941507,0.00003603807],"domain_scores_gemma":[0.99988,0.00001793819,0.00003510571,0.00001133947,0.00003376804,0.0000218961],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002687777,0.00002874729,0.001438789,0.0001533249,0.000009171325,0.0001476655,0.00004347327,0.00002584547,0.9951969,0.0000435265,0.00004436476,0.002599412],"study_design_scores_gemma":[0.0001073529,0.002142452,0.2356291,0.00008815577,0.0001055138,0.004524149,0.0004136168,0.0007757098,0.7443169,0.0002058259,0.01165939,0.00003182455],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9663904,0.02789538,0.002364653,0.0001406052,0.00004891304,0.00008933201,0.001302968,0.00005890284,0.00170879],"genre_scores_gemma":[0.9866483,0.005746906,0.001857433,0.00005602366,0.00003235685,0.0001150932,0.001664354,0.00000765669,0.003871892],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001267184,"threshold_uncertainty_score":0.004239202,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02090081347745909,"score_gpt":0.3162736502343816,"score_spread":0.2953728367569225,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}