{"id":"W1568585026","doi":"10.1186/ar1439","title":"Expression and regulation of microsomal prostaglandin E synthase-1 in human osteoarthritic cartilage and chondrocytes.","year":2004,"lang":"en","type":"article","venue":"Arthritis Research","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":85,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Hôpital Notre-Dame","funders":"Canadian Arthritis Network; School of Medicine, University of California, San Diego; Menzies Institute for Medical Research; National Cancer Institute; Arthritis Society; University of North Carolina at Chapel Hill; Genentech; National Institutes of Health; Biogen; Lupus Research Institute; Pfizer; Natural Sciences and Engineering Research Council of Canada; Dutch Arthritis Association; Oesterreichische Nationalbank; Deutsche Forschungsgemeinschaft; Nuffield Foundation; Physiotherapy Foundation of Canada; Canadian Institutes of Health Research; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Lupus Research Alliance; Wellcome Trust; Newcastle University; National Institute of Allergy and Infectious Diseases; Howard Hughes Medical Institute; Austrian Science Fund; Arthritis Foundation","keywords":"Western blot; Prostaglandin E2; Downregulation and upregulation; Chemistry; Messenger RNA; Molecular biology; Cartilage; Tumor necrosis factor alpha; Gene expression; Cyclooxygenase; Real-time polymerase chain reaction; Prostaglandin; Biology; Endocrinology; Enzyme; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007075288,0.0001021811,0.0002664995,0.0003104905,0.0001350409,0.00002398143,0.00003636691,0.0001111518,0.0000342558],"category_scores_gemma":[0.0002038296,0.00009573818,0.00002315298,0.0002020806,0.0003469754,0.0001326029,0.00007159817,0.0002696845,0.000004267453],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004833469,"about_ca_system_score_gemma":0.000108907,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001449619,"about_ca_topic_score_gemma":0.0004327675,"domain_scores_codex":[0.9986145,0.0001113322,0.0002713468,0.0002703058,0.0003884131,0.0003441344],"domain_scores_gemma":[0.9993862,0.0001254944,0.00003502738,0.0001892786,0.0001000153,0.0001639636],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001995855,0.00006957079,0.03008773,0.0002827415,0.000001891058,0.0001787064,0.0009301302,0.000001268736,0.9645609,0.0003637649,0.00003575835,0.003287914],"study_design_scores_gemma":[0.00831772,0.0008478079,0.08767266,0.002528582,0.000003098766,0.0001352851,0.0002298535,0.00001018789,0.8994344,0.0005654264,0.0001515557,0.0001033912],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954396,0.003311257,0.000003601433,0.0001151832,0.00002827811,0.0007123915,0.000005988039,0.00001566036,0.0003680539],"genre_scores_gemma":[0.9990997,0.0005298493,0.0001176304,0.00001222319,0.00006702364,0.00005263235,0.00001567896,0.00001716321,0.00008810056],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06512651,"threshold_uncertainty_score":0.390409,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02090081347745909,"score_gpt":0.3162736502343816,"score_spread":0.2953728367569225,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}