{"id":"W1569027868","doi":"10.1002/stem.1600","title":"The SUMO Conjugating Enzyme Ubc9 Is Required for Inducing and Maintaining Stem Cell Pluripotency","year":2013,"lang":"en","type":"article","venue":"Stem Cells","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre; Occupational Cancer Research Centre","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; McGill University","keywords":"SUMO protein; Reprogramming; Biology; Homeobox protein NANOG; SOX2; Embryonic stem cell; Induced pluripotent stem cell; Gene knockdown; Cell biology; Stem cell; Ubiquitin; Rex1; Cellular differentiation; Molecular biology; Ubiquitin-conjugating enzyme; Ubiquitin ligase; Cell; Biochemistry; Apoptosis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001314143,0.0003939087,0.0003351967,0.0002967126,0.0003596451,0.0006284081,0.0002180301,0.0003553311,0.001495309],"category_scores_gemma":[0.0001968018,0.0001652024,0.0002566893,0.0003664828,0.0002470418,0.0002640266,0.0003193141,0.0003996384,0.001522301],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003564809,"about_ca_system_score_gemma":0.0003540127,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005670344,"about_ca_topic_score_gemma":0.0006140782,"domain_scores_codex":[0.9998049,0.00001811185,0.00002666892,0.0000461042,0.00007360197,0.00003058523],"domain_scores_gemma":[0.9998104,0.00001674901,0.00005821955,0.00002745304,0.000038931,0.0000482651],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005631807,0.00001089954,0.0009513341,0.00004997062,0.00000732822,0.0002553699,0.000009280132,0.00008947476,0.9917244,0.0003646393,0.0001978969,0.00628316],"study_design_scores_gemma":[0.000007103934,0.00005131357,0.01054541,0.000008048538,0.00001714552,0.0008643867,0.00001809133,0.0006192765,0.9702066,0.0003132068,0.0173423,0.00000719856],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.936177,0.01195583,0.03128184,0.0007067313,0.0003280661,0.00009756428,0.006077666,0.00127194,0.01210335],"genre_scores_gemma":[0.9781662,0.00321942,0.007319578,0.0001300353,0.00004578437,0.00003260157,0.003432961,0.00009890651,0.007554412],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001495309,"threshold_uncertainty_score":0.00500226,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0176626588025387,"score_gpt":0.2509382575382711,"score_spread":0.2332755987357324,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}