{"id":"W1569027868","doi":"10.1002/stem.1600","title":"The SUMO Conjugating Enzyme Ubc9 Is Required for Inducing and Maintaining Stem Cell Pluripotency","year":2013,"lang":"en","type":"article","venue":"Stem Cells","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre; Occupational Cancer Research Centre","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; McGill University","keywords":"SUMO protein; Reprogramming; Biology; Homeobox protein NANOG; SOX2; Embryonic stem cell; Induced pluripotent stem cell; Gene knockdown; Cell biology; Stem cell; Ubiquitin; Rex1; Cellular differentiation; Molecular biology; Ubiquitin-conjugating enzyme; Ubiquitin ligase; Cell; Biochemistry; Apoptosis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007483743,0.0002568399,0.000221604,0.00004694701,0.0005224352,0.0002206481,0.0003916514,0.0002017331,0.00002134404],"category_scores_gemma":[0.00001618477,0.0002017136,0.0001133126,0.00009794671,0.0001448147,0.00001601295,0.0003360418,0.0001771713,0.00006707588],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003131654,"about_ca_system_score_gemma":0.0001022501,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006007538,"about_ca_topic_score_gemma":0.00001135791,"domain_scores_codex":[0.9978307,0.0001409064,0.0004108947,0.0006096527,0.0002629283,0.0007448772],"domain_scores_gemma":[0.9986759,0.0001979663,0.0001837352,0.0005487623,0.0002017089,0.0001919078],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003654253,0.00001802916,0.0002355024,0.0001048631,0.00004647536,0.000002554157,0.0003139162,0.00001800737,0.9786304,0.00005608179,0.006107626,0.01443005],"study_design_scores_gemma":[0.0007773891,0.0002833898,0.00007104984,0.00004585837,0.00001670554,0.000008968547,0.002036117,0.001268395,0.957607,0.0001039126,0.03748465,0.0002965271],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9898176,0.003464516,0.001007821,0.0005611532,0.0002783895,0.001414113,0.00003848413,0.00002813549,0.003389779],"genre_scores_gemma":[0.9830524,0.000471581,0.0005222207,0.0002738519,0.0002176636,0.0001764904,0.00001733058,0.00006036074,0.01520811],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03137702,"threshold_uncertainty_score":0.8225641,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0176626588025387,"score_gpt":0.2509382575382711,"score_spread":0.2332755987357324,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}