{"id":"W1569444286","doi":"10.1038/cddis.2015.102","title":"Peptides derived from the dependence receptor ALK are proapoptotic for ALK-positive tumors","year":2015,"lang":"en","type":"article","venue":"Cell Death and Disease","topic":"Neuroblastoma Research and Treatments","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Mount Sinai Hospital; Lunenfeld-Tanenbaum Research Institute","funders":"Fondation de France; Institut National de la Santé et de la Recherche Médicale","keywords":"Anaplastic lymphoma kinase; Cancer research; Neuroblastoma; Apoptosis; Tyrosine kinase; ALK inhibitor; Molecular biology; Crizotinib; Biology; Receptor tyrosine kinase; Cell culture; Kinase; Cytotoxic T cell; Chemistry; Signal transduction; Cell biology; Biochemistry; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001079642,0.0003348454,0.0001844462,0.0001484984,0.0001229179,0.0001772139,0.0001288321,0.0002468894,0.001135092],"category_scores_gemma":[0.000155879,0.00009403231,0.000199003,0.0001331894,0.0001268864,0.0001795519,0.0001643465,0.0004072692,0.0004309228],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001290989,"about_ca_system_score_gemma":0.0001032432,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008747814,"about_ca_topic_score_gemma":0.0001270138,"domain_scores_codex":[0.9999092,0.00001766773,0.000008240034,0.00001691665,0.00002943332,0.00001852449],"domain_scores_gemma":[0.9999074,0.00001782751,0.00002990202,0.000008949917,0.00001300401,0.00002294124],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009422789,0.00001226568,0.0001035605,0.00004773894,0.000002614443,0.00007602246,0.000008668366,0.00008225007,0.9972555,0.0000489599,0.00002599809,0.002242095],"study_design_scores_gemma":[0.00002993454,0.0007167961,0.00309408,0.00001142417,0.00002384358,0.00133234,0.00002039323,0.0004130711,0.9885654,0.00008923127,0.005695977,0.000007592936],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9885513,0.004998171,0.00442582,0.0001155316,0.00004564151,0.00005998771,0.0002780322,0.00005452242,0.001471096],"genre_scores_gemma":[0.9893442,0.002627338,0.005262019,0.0001030466,0.0000329779,0.00004104495,0.0005722489,0.00001687947,0.002000152],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001135092,"threshold_uncertainty_score":0.003797233,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03528861986147126,"score_gpt":0.2798446445445675,"score_spread":0.2445560246830962,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}