{"id":"W1569477387","doi":"10.4049/jimmunol.178.11.7458","title":"Immunization of HLA Class I Transgenic Mice Identifies Autoantigenic Epitopes Eliciting Dominant Responses in Type 1 Diabetes Patients","year":2007,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Diabetes and associated disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hotel Dieu Hospital","funders":"","keywords":"Epitope; Immunology; Biology; Human leukocyte antigen; CD8; Antigen; Type 1 diabetes; Diabetes mellitus; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001197665,0.00009678158,0.0002113697,0.0001271208,0.00005425661,0.000006793704,0.0002899542,0.0001235259,0.000007035523],"category_scores_gemma":[0.0004383631,0.00007189995,0.00008856147,0.0001903395,0.0001242235,0.000009526878,0.00005163408,0.0001365311,0.000001301397],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001721165,"about_ca_system_score_gemma":0.00006260336,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002135712,"about_ca_topic_score_gemma":0.0000611896,"domain_scores_codex":[0.9987972,0.0002562695,0.0005370069,0.000072579,0.00009780393,0.0002391507],"domain_scores_gemma":[0.9989652,0.000142329,0.0004732053,0.0001409168,0.0002626823,0.00001567426],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005668838,0.0001037722,0.02901828,0.000008836172,0.0001707168,4.453011e-7,0.0003185476,0.00004741638,0.9636163,0.000009699284,0.00007628607,0.006062872],"study_design_scores_gemma":[0.001189998,0.0007086381,0.2622133,0.00006544924,0.00005629603,0.000003235994,0.0009494548,0.000006830145,0.7336541,0.0001157021,0.0009352856,0.0001016833],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909288,0.008406624,0.0000599881,0.0001071058,0.0003627328,0.00007251344,0.000003666506,0.000001624637,0.00005695793],"genre_scores_gemma":[0.9969417,0.002841082,0.00004002994,0.00005702582,0.00003818135,4.321246e-7,0.00001122964,0.00001226966,0.00005798643],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.233195,"threshold_uncertainty_score":0.2931995,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005547695918205515,"score_gpt":0.2337408883071283,"score_spread":0.2281931923889228,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}