{"id":"W1570116363","doi":"10.4049/jimmunol.0902919","title":"Mutational Analyses Reveal that the Staphylococcal Immune Evasion Molecule Sbi and Complement Receptor 2 (CR2) Share Overlapping Contact Residues on C3d: Implications for the Controversy Regarding the CR2/C3d Cocrystal Structure","year":2010,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Antimicrobial Resistance in Staphylococcus","field":"Medicine","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Biotechnology and Biological Sciences Research Council; Canadian Institutes of Health Research","keywords":"Cocrystal; Binding site; Chemistry; Mutagenesis; Plasma protein binding; Binding domain; Complement system; Site-directed mutagenesis; Biochemistry; Biophysics; Molecule; Biology; Antibody; Mutation; Gene; Genetics; Hydrogen bond; Mutant","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001189501,0.000260995,0.0004992914,0.000102259,0.001196684,0.00009293778,0.0006476405,0.0001313362,0.0001369687],"category_scores_gemma":[0.001007667,0.0001100777,0.0002779451,0.0001798405,0.0006328343,0.0001146776,0.000139537,0.001180692,0.000001716301],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001257109,"about_ca_system_score_gemma":0.0002289507,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009039822,"about_ca_topic_score_gemma":0.000158087,"domain_scores_codex":[0.998049,0.0003559449,0.0006748211,0.0001965503,0.0003465787,0.0003770693],"domain_scores_gemma":[0.9938547,0.003858289,0.0009576405,0.0006416133,0.000633239,0.00005454506],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.003404517,0.00004575509,0.001257291,0.00001991764,0.000963679,0.000003398861,0.0008393943,0.00007859596,0.9819077,0.003136849,0.007054894,0.001287989],"study_design_scores_gemma":[0.008730418,0.002185142,0.8510699,0.0005675238,0.001746535,0.001294347,0.01369632,0.0002392503,0.08436077,0.003012862,0.03266869,0.0004282586],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9543554,0.003795854,0.001405603,0.03815368,0.0004768347,0.001330803,0.0003564848,0.00001393005,0.0001114704],"genre_scores_gemma":[0.9975879,0.0004733471,0.0003409403,0.001070525,0.0003509079,0.00002425406,0.00003753405,0.00002979376,0.00008485241],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8975469,"threshold_uncertainty_score":0.9204043,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03868215517641475,"score_gpt":0.3368497243620509,"score_spread":0.2981675691856361,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}