{"id":"W1570116363","doi":"10.4049/jimmunol.0902919","title":"Mutational Analyses Reveal that the Staphylococcal Immune Evasion Molecule Sbi and Complement Receptor 2 (CR2) Share Overlapping Contact Residues on C3d: Implications for the Controversy Regarding the CR2/C3d Cocrystal Structure","year":2010,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Antimicrobial Resistance in Staphylococcus","field":"Medicine","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Biotechnology and Biological Sciences Research Council; Canadian Institutes of Health Research","keywords":"Cocrystal; Binding site; Chemistry; Mutagenesis; Plasma protein binding; Binding domain; Complement system; Site-directed mutagenesis; Biochemistry; Biophysics; Molecule; Biology; Antibody; Mutation; Gene; Genetics; Hydrogen bond; Mutant","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001228218,0.0002853756,0.0002375098,0.00009717099,0.0002048535,0.0002504619,0.0003209873,0.0002761308,0.001096135],"category_scores_gemma":[0.0002549741,0.00009640677,0.0002836656,0.0001130537,0.0002384387,0.0001552203,0.0002549447,0.0004678071,0.0002744479],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004895565,"about_ca_system_score_gemma":0.0002816198,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002281645,"about_ca_topic_score_gemma":0.002252388,"domain_scores_codex":[0.9998993,0.00001513153,0.000006372761,0.00002132743,0.00004161098,0.00001637523],"domain_scores_gemma":[0.9998869,0.00004683685,0.00002206987,0.00001068109,0.00001500555,0.00001848173],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002475652,0.00005584295,0.001901836,0.00006030806,0.00003214319,0.0006158341,0.00008511899,0.0007923683,0.9928631,0.0008172019,0.000116594,0.002411937],"study_design_scores_gemma":[0.00003939077,0.0001490526,0.006344872,0.00000896965,0.00005159777,0.001182261,0.00007671172,0.007106213,0.9831831,0.0001827196,0.00166022,0.00001490251],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943746,0.0003474046,0.00386308,0.00009047271,0.000009767744,0.00001315536,0.0001178712,0.0000324621,0.001151164],"genre_scores_gemma":[0.9970189,0.00008754215,0.002395127,0.00005120245,0.000001732994,0.000007145715,0.0001202856,0.00001025364,0.0003077648],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002281645,"threshold_uncertainty_score":0.004536748,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03868215517641475,"score_gpt":0.3368497243620509,"score_spread":0.2981675691856361,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}