{"id":"W1570480111","doi":"","title":"A novel approach to prepare a liposomal irinotecan formulations that exhibit significant therapeutic activity in vivo","year":2004,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Celator Pharmaceuticals (Canada); BC Cancer Agency","funders":"","keywords":"Liposome; Chemistry; Irinotecan; SN-38; Topoisomerase; Camptothecin; In vivo; Combinatorial chemistry; Hydrolysis; Drug delivery; Stereochemistry; Biophysics; Chromatography; Enzyme; Organic chemistry; Biochemistry; Colorectal cancer; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001430502,0.0003616,0.0001495264,0.0002084225,0.0001302578,0.0002588024,0.0001732343,0.0003261642,0.0009400276],"category_scores_gemma":[0.00009267937,0.0001489396,0.0001570141,0.0001026928,0.000187736,0.0002465114,0.0001803627,0.0006069746,0.000474075],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003843196,"about_ca_system_score_gemma":0.0003535114,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003688197,"about_ca_topic_score_gemma":0.0006740444,"domain_scores_codex":[0.999935,0.000007599022,0.00000591598,0.00001821301,0.00002518185,0.000008038308],"domain_scores_gemma":[0.999957,0.00000514001,0.00001408533,0.000005028254,0.00001113611,0.000007753563],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001376887,0.00002071469,0.00002482092,0.00002757003,0.000002398618,0.00002245612,0.000006611142,0.00005241345,0.9979849,0.0001334327,0.00003016826,0.001680703],"study_design_scores_gemma":[0.00001322503,0.0001323408,0.0002192981,0.000003407661,0.000006037687,0.0001762263,0.000003618039,0.0004775799,0.9957319,0.00002994937,0.003203526,0.000002982795],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.834776,0.00371488,0.151822,0.00092768,0.0001763929,0.0009468808,0.0005999785,0.0004785949,0.006557595],"genre_scores_gemma":[0.8596222,0.002209335,0.1292926,0.0002995684,0.00003123733,0.0004311815,0.0004839316,0.00005058887,0.007579344],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009400276,"threshold_uncertainty_score":0.003144681,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1113584833317969,"score_gpt":0.3797676078924195,"score_spread":0.2684091245606226,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}