{"id":"W1570960267","doi":"10.1111/j.1600-0854.2005.00366.x","title":"Dominant and Recessive Distal Renal Tubular Acidosis Mutations of Kidney Anion Exchanger 1 Induce Distinct Trafficking Defects in MDCK Cells","year":2005,"lang":"en","type":"article","venue":"Traffic","topic":"Ion Transport and Channel Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":88,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"Canadian Institutes of Health Research; Kidney Foundation of Canada","keywords":"Biology; Distal renal tubular acidosis; Mutant; Intercalated Cell; Epithelial polarity; Apical membrane; Endoplasmic reticulum; Golgi apparatus; Cell biology; Renal tubular acidosis; Molecular biology; Kidney; Biochemistry; Genetics; Epithelium; Gene; Endocrinology; Metabolic acidosis; Acidosis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000111814,0.0001310142,0.0001447662,0.00007263108,0.00005102957,0.00001019249,0.00006367006,0.0001322679,0.00001662381],"category_scores_gemma":[0.00002322845,0.0001257244,0.00005728058,0.0001221719,0.00007268376,0.00000984777,0.00001374473,0.00006998907,0.000001793113],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001493559,"about_ca_system_score_gemma":0.0000498448,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006381904,"about_ca_topic_score_gemma":0.0001489665,"domain_scores_codex":[0.9992067,0.00003563768,0.0002282713,0.0002516098,0.0001032705,0.0001745288],"domain_scores_gemma":[0.9996477,0.000009779011,0.00009070578,0.0001162023,0.00003862446,0.00009696705],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001085289,0.0001278178,0.0005836628,0.00005297162,0.00001675592,0.000004897807,0.0009747581,0.00267237,0.9843197,0.00001241149,0.0001502672,0.01097579],"study_design_scores_gemma":[0.001222824,0.0001875226,0.01481376,0.00009769513,0.00004274744,0.00000978957,0.0002191259,0.00147927,0.9788619,0.000007437324,0.002815679,0.0002422661],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987542,0.0003747182,0.0004048861,0.0001331923,0.00007050773,0.0001660689,0.00002962356,0.000008755314,0.00005806769],"genre_scores_gemma":[0.9991015,0.00009301451,0.000190857,0.00003145278,0.0001318604,0.00001594197,0.000340646,0.00001624281,0.00007844431],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01423009,"threshold_uncertainty_score":0.5126892,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00830932749812434,"score_gpt":0.2281881297551813,"score_spread":0.2198788022570569,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}