{"id":"W1570960267","doi":"10.1111/j.1600-0854.2005.00366.x","title":"Dominant and Recessive Distal Renal Tubular Acidosis Mutations of Kidney Anion Exchanger 1 Induce Distinct Trafficking Defects in MDCK Cells","year":2005,"lang":"en","type":"article","venue":"Traffic","topic":"Ion Transport and Channel Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":88,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"Canadian Institutes of Health Research; Kidney Foundation of Canada","keywords":"Biology; Distal renal tubular acidosis; Mutant; Intercalated Cell; Epithelial polarity; Apical membrane; Endoplasmic reticulum; Golgi apparatus; Cell biology; Renal tubular acidosis; Molecular biology; Kidney; Biochemistry; Genetics; Epithelium; Gene; Endocrinology; Metabolic acidosis; Acidosis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002198945,0.0004925625,0.000348263,0.0003221372,0.0002100767,0.0003532059,0.0002909312,0.0004962833,0.001147553],"category_scores_gemma":[0.0002056818,0.0002486169,0.0003972723,0.0001981655,0.0002515921,0.0002008727,0.0003869547,0.0006294831,0.0005384324],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004432301,"about_ca_system_score_gemma":0.0002290754,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001232723,"about_ca_topic_score_gemma":0.0014954,"domain_scores_codex":[0.9996401,0.00005695793,0.0000778187,0.00007202629,0.00008693806,0.00006609485],"domain_scores_gemma":[0.9998043,0.00004072227,0.00004805556,0.00002442427,0.00002082594,0.00006172145],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008435515,0.00001506182,0.000132534,0.00001431091,0.000002956335,0.00008669151,0.00001554403,0.00005346606,0.999358,0.00006686759,0.00001339325,0.0001569137],"study_design_scores_gemma":[0.00005647691,0.0003119783,0.006919714,0.000009465101,0.00002107148,0.0009551814,0.00008497989,0.00214005,0.9876606,0.00006166003,0.001764069,0.00001455116],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965047,0.0003709544,0.00153182,0.00006848124,0.00002657861,0.00003075015,0.0007347087,0.00004695528,0.0006850191],"genre_scores_gemma":[0.9939574,0.0003772584,0.002013284,0.00007578196,0.00000590013,0.00008284857,0.001035793,0.00003919503,0.002412541],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001232723,"threshold_uncertainty_score":0.003838897,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00830932749812434,"score_gpt":0.2281881297551813,"score_spread":0.2198788022570569,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}