{"id":"W1571365882","doi":"10.18433/j30c7d","title":"Nanotherapeutics to Overcome Conventional Cancer Chemotherapy Limitations","year":2011,"lang":"en","type":"review","venue":"Journal of Pharmacy & Pharmaceutical Sciences","topic":"Nanoparticle-Based Drug Delivery","field":"Materials Science","cited_by":557,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Chemosensitizer; Multiple drug resistance; Mesoporous silica; Poloxamer; Chemotherapy; Bioavailability; Cancer; Cancer cell; Nanomedicine; Solid lipid nanoparticle; Nanotechnology; Drug resistance; Chemistry; Nanoparticle; Liposome; Drug delivery; Micelle; Pharmacology; Aqueous solution; Materials science; Medicine; Biochemistry; Biology; Polymer; Antibiotics; Organic chemistry; Internal medicine","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003441444,0.0007218007,0.0009299531,0.001645994,0.0002971287,0.0005683916,0.0005890659,0.0009547322,0.003063692],"category_scores_gemma":[0.0002504825,0.0002492088,0.0004154264,0.001127642,0.0003673009,0.0008768832,0.0004850321,0.001577549,0.001945608],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005408672,"about_ca_system_score_gemma":0.0006768423,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005440986,"about_ca_topic_score_gemma":0.001220838,"domain_scores_codex":[0.9998272,0.0000244838,0.00001448515,0.00002969117,0.00008616154,0.00001797184],"domain_scores_gemma":[0.9998968,0.00003822983,0.0000161235,0.000005557569,0.00003464472,0.000008634106],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005002665,0.000181054,0.0001328729,0.01187639,0.00006090935,0.0003766045,0.0001083032,0.0008210135,0.0285933,0.01120128,0.01630608,0.9302922],"study_design_scores_gemma":[0.00001509024,0.0001293985,0.0003714032,0.0008971238,0.00003866649,0.001360154,0.00004211659,0.0002268228,0.007279823,0.001787973,0.9878377,0.00001364866],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0007945828,0.9932534,0.001124986,0.0003300551,0.0003367549,0.00002142604,0.0000162262,0.00002688891,0.004095671],"genre_scores_gemma":[0.004321175,0.9888284,0.001634231,0.0002972124,0.0001741612,0.00003088409,0.00003717496,0.000004605964,0.004672273],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003063692,"threshold_uncertainty_score":0.01024902,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2875925810511675,"score_gpt":0.4674319891566605,"score_spread":0.179839408105493,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}