{"id":"W1572122915","doi":"10.4049/jimmunol.1401002","title":"Anti-GITR Agonist Therapy Intrinsically Enhances CD8 T Cell Responses to Chronic Lymphocytic Choriomeningitis Virus (LCMV), Thereby Circumventing LCMV-Induced Downregulation of Costimulatory GITR Ligand on APC","year":2014,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research; National Institutes of Health","keywords":"Lymphocytic choriomeningitis; CD8; Immunology; CTL*; Cytotoxic T cell; Immune system; T cell; Biology; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001390858,0.0004351118,0.0004431105,0.0001529075,0.0001332131,0.0002808071,0.0001849859,0.0002947696,0.001031958],"category_scores_gemma":[0.0001046853,0.00010886,0.0001725543,0.0001003227,0.0002250313,0.0001403824,0.0001683271,0.001290947,0.0003004536],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001773497,"about_ca_system_score_gemma":0.0002265946,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001935388,"about_ca_topic_score_gemma":0.0007038111,"domain_scores_codex":[0.9998088,0.00003830369,0.00001528705,0.00003204919,0.00003614574,0.00006946434],"domain_scores_gemma":[0.9998975,0.00002241093,0.00002527495,0.00001169109,0.000008035461,0.00003520603],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000327777,0.000237607,0.0001327389,0.0000430627,0.00000564738,0.00003644562,0.0000188971,0.00006270452,0.9968818,0.00002917299,0.00004943278,0.002174687],"study_design_scores_gemma":[0.0001442833,0.009367213,0.005405593,0.00001590543,0.00005578895,0.0003226664,0.00003494105,0.0007774717,0.9805678,0.00004359125,0.003258361,0.000006472604],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976779,0.0008672815,0.0003729605,0.00006143859,0.00004129227,0.00002946841,0.00007163847,0.00004857505,0.0008295891],"genre_scores_gemma":[0.9959991,0.0007312938,0.001055031,0.0000759629,0.00005036907,0.00006786153,0.0001716527,0.000009477635,0.001839239],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001031958,"threshold_uncertainty_score":0.003452241,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01351981451890197,"score_gpt":0.2414690747814165,"score_spread":0.2279492602625146,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}