{"id":"W1572235723","doi":"10.1046/j.1399-3011.2003.00106.x","title":"Effects of single <scp>d</scp>‐amino acid substitutions on disruption of β‐sheet structure and hydrophobicity in cyclic 14‐residue antimicrobial peptide analogs related to gramicidin S","year":2004,"lang":"en","type":"article","venue":"Journal of Peptide Research","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":88,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; University of Alberta","funders":"National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; National Heart, Lung, and Blood Institute","keywords":"Gramicidin S; Diastereomer; Amino acid; Gramicidin; Peptide; Cyclic peptide; Residue (chemistry); Stereochemistry; Chemistry; Norleucine; Dipeptide; Biochemistry; Membrane; Methionine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002233603,0.0003316613,0.0002314738,0.0001161311,0.0001143655,0.0002399386,0.0002586337,0.0003299089,0.001109697],"category_scores_gemma":[0.0003711759,0.0001509322,0.0001817221,0.0001254913,0.0002821266,0.0001954769,0.0002065142,0.0005523773,0.000201714],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002112689,"about_ca_system_score_gemma":0.0001904353,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004715006,"about_ca_topic_score_gemma":0.0005356587,"domain_scores_codex":[0.9998032,0.00006235158,0.00003064445,0.00003225528,0.00003355372,0.00003797735],"domain_scores_gemma":[0.9996778,0.0001015841,0.00009933482,0.00002237434,0.00002190781,0.00007694235],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001124963,0.0002547781,0.0002524812,0.0000401434,0.00002137319,0.0001390012,0.00001960032,0.0006040226,0.9954834,0.00006564012,0.00004567196,0.001948855],"study_design_scores_gemma":[0.00009579567,0.003640423,0.001831668,0.000008460459,0.00003459294,0.000205697,0.00002767699,0.001339046,0.9917195,0.00002460096,0.00106112,0.00001144176],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991046,0.0002385614,0.0001497538,0.00001736107,0.00001109499,0.00001413355,0.00003887258,0.000007735378,0.0004179706],"genre_scores_gemma":[0.998902,0.0002409461,0.000485078,0.00004047136,0.000005368816,0.00001131422,0.00006320154,0.000009987069,0.0002417321],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001109697,"threshold_uncertainty_score":0.003712296,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01690908775529265,"score_gpt":0.2854986844880797,"score_spread":0.2685895967327871,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}