{"id":"W1572235723","doi":"10.1046/j.1399-3011.2003.00106.x","title":"Effects of single <scp>d</scp>‐amino acid substitutions on disruption of β‐sheet structure and hydrophobicity in cyclic 14‐residue antimicrobial peptide analogs related to gramicidin S","year":2004,"lang":"en","type":"article","venue":"Journal of Peptide Research","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":88,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; University of Alberta","funders":"National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; National Heart, Lung, and Blood Institute","keywords":"Gramicidin S; Diastereomer; Amino acid; Gramicidin; Peptide; Cyclic peptide; Residue (chemistry); Stereochemistry; Chemistry; Norleucine; Dipeptide; Biochemistry; Membrane; Methionine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009621794,0.0002615768,0.0007555806,0.001227197,0.0002016228,0.0000328583,0.0003608376,0.0003988663,0.00002326651],"category_scores_gemma":[0.001149329,0.0002252685,0.0001997198,0.0007846158,0.0008545554,0.0002711965,0.0001634465,0.001326534,0.00001799611],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002577376,"about_ca_system_score_gemma":0.00023312,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006815568,"about_ca_topic_score_gemma":0.0003576326,"domain_scores_codex":[0.9973864,0.000530084,0.0009040674,0.0003195803,0.000229082,0.00063078],"domain_scores_gemma":[0.9980088,0.0007884954,0.0004688292,0.0002418236,0.0003988603,0.0000932082],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003136816,0.000620426,0.003130277,0.0002043871,0.0001425742,0.0000867454,0.00155329,0.00162303,0.9900692,0.000826941,0.001186645,0.000242836],"study_design_scores_gemma":[0.002486772,0.001720771,0.0588439,0.0009947519,0.00004597738,0.0002994471,0.0004888981,0.000001671635,0.9336694,0.001186881,0.0001566407,0.0001048233],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980678,0.0006006235,0.0000715655,0.0002487978,0.0002372602,0.0004121717,0.00007480475,0.00001043863,0.0002765192],"genre_scores_gemma":[0.9988549,0.0003168419,0.0003234459,0.00003955125,0.00004548887,0.000002299932,0.00002110277,0.00002592419,0.0003704189],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0563997,"threshold_uncertainty_score":0.9186184,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01690908775529265,"score_gpt":0.2854986844880797,"score_spread":0.2685895967327871,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}