{"id":"W1572596428","doi":"10.4049/jimmunol.172.2.981","title":"A Switch in Costimulation from CD28 to 4-1BB during Primary versus Secondary CD8 T Cell Response to Influenza In Vivo","year":2004,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":126,"is_retracted":false,"has_abstract":true,"ca_institutions":"Research & Development Corporation; McMaster University; University of Toronto","funders":"National Institute of Allergy and Infectious Diseases","keywords":"In vivo; CD28; CD8; Cytotoxic T cell; Immunology; Chemistry; Cell biology; Biology; Immune system; In vitro; Genetics; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002934523,0.0006115364,0.0004256232,0.000312536,0.0001677087,0.0003997293,0.0004150462,0.000616158,0.001488735],"category_scores_gemma":[0.0002365337,0.0003128699,0.0003207502,0.000118106,0.0002994476,0.0003013326,0.0002093565,0.002007686,0.0005959918],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003410259,"about_ca_system_score_gemma":0.0002981375,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003203126,"about_ca_topic_score_gemma":0.0006155273,"domain_scores_codex":[0.9995859,0.00007748842,0.00005345939,0.00007629188,0.0000679633,0.0001389138],"domain_scores_gemma":[0.9996448,0.00007832125,0.00007772316,0.00004555334,0.0000263887,0.0001272827],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002822508,0.00009838955,0.0001174283,0.00001938581,0.000003114786,0.00003258335,0.000009483382,0.00003847379,0.9989058,0.00004654495,0.00002474349,0.0004218739],"study_design_scores_gemma":[0.0001364304,0.001704095,0.004159988,0.0000113968,0.00002710867,0.0002762543,0.00002015931,0.0007456133,0.9920775,0.00007005023,0.0007621366,0.000009223973],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975154,0.0003841922,0.0007612656,0.0001084456,0.00007080684,0.00005887917,0.0002690231,0.00009694812,0.0007350753],"genre_scores_gemma":[0.9930352,0.0003969887,0.002714286,0.0002319975,0.00004619795,0.0001610106,0.0005417423,0.00005058758,0.002822026],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001488735,"threshold_uncertainty_score":0.004980326,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01138397670992257,"score_gpt":0.2501765620535497,"score_spread":0.2387925853436271,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}