{"id":"W1572799672","doi":"10.4049/jimmunol.1400030","title":"Differential Roles for Bim and Nur77 in Thymocyte Clonal Deletion Induced by Ubiquitous Self-Antigen","year":2015,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Nuclear Receptors and Signaling","field":"Neuroscience","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Faculty of Medicine and Dentistry, University of Alberta; Canadian Institutes of Health Research","keywords":"Nerve growth factor IB; Biology; Clonal deletion; Negative selection; T-cell receptor; Transgene; Thymocyte; Context (archaeology); Cell biology; Genetically modified mouse; Programmed cell death; Apoptosis; Transcription factor; T cell; Immunology; Genetics; Nuclear receptor; Gene; Immune system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004058523,0.00008308125,0.0001830992,0.00008883194,0.0000809937,0.00002523725,0.0002312178,0.00007727444,0.00002025858],"category_scores_gemma":[0.0001484419,0.00005362711,0.00003958675,0.00007161137,0.00006817748,0.0001005797,0.00005444587,0.0002519786,0.000004968127],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003870309,"about_ca_system_score_gemma":0.00004752483,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000155599,"about_ca_topic_score_gemma":0.000004881242,"domain_scores_codex":[0.999079,0.0002595175,0.0002702201,0.00008286998,0.0001267738,0.0001815467],"domain_scores_gemma":[0.9994401,0.0001826613,0.000210339,0.00007394533,0.00005421364,0.00003875622],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005757178,0.00006242285,0.0001379043,0.000001982677,0.00001459505,0.000002599661,0.0008089,0.000006344736,0.99462,0.0002861703,0.0002398638,0.003243535],"study_design_scores_gemma":[0.003671051,0.001861202,0.002357362,0.00004019005,0.00004355334,0.0006139721,0.0008597221,0.0007900924,0.9784151,0.003740462,0.007418707,0.0001885772],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978116,0.0006104829,0.0003995357,0.0005962792,0.0004409604,0.00009811013,0.000002285161,0.000008559281,0.00003225301],"genre_scores_gemma":[0.9992431,0.0004141914,0.0000872122,0.0001172587,0.0001079459,0.000001164307,3.767584e-7,0.00001184769,0.00001683464],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01620485,"threshold_uncertainty_score":0.218685,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03113734981799648,"score_gpt":0.264347971467132,"score_spread":0.2332106216491355,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}