{"id":"W1573496496","doi":"10.1111/j.1471-4159.2005.03363.x","title":"Selective loss of basal forebrain cholinergic neurons by 192 IgG‐saporin is associated with decreased phosphorylation of Ser<sup>9</sup> glycogen synthase kinase‐3β","year":2005,"lang":"en","type":"article","venue":"Journal of Neurochemistry","topic":"Nicotinic Acetylcholine Receptors Study","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; McGill University","funders":"Canadian Institutes of Health Research; Canada Research Chairs; Alzheimer Society","keywords":"GSK-3; Cholinergic neuron; Basal forebrain; Phosphorylation; Protein kinase B; Internal medicine; Biology; Cholinergic; Endocrinology; Forebrain; Glycogen synthase; Saporin; Kinase; GSK3B; Tau protein; Cell biology; Chemistry; Biochemistry; Alzheimer's disease; Central nervous system; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001670381,0.0006640108,0.0005328844,0.0003156755,0.0001562694,0.0002918007,0.0003045218,0.0003897105,0.001634198],"category_scores_gemma":[0.00009615485,0.0002348826,0.0004107101,0.000183304,0.0003852634,0.0002418737,0.000229464,0.0009763658,0.000547781],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000432347,"about_ca_system_score_gemma":0.0003998617,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001289964,"about_ca_topic_score_gemma":0.002167187,"domain_scores_codex":[0.9998135,0.00001385785,0.00002579042,0.00004035907,0.00004315578,0.00006338676],"domain_scores_gemma":[0.9998746,0.00001177566,0.00004086987,0.00001469864,0.00001184283,0.00004628377],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001716442,0.00003787521,0.0001432101,0.00003200199,0.00000923459,0.00007700847,0.00001081346,0.00001432505,0.9989294,0.00002701589,0.00002171465,0.0005256743],"study_design_scores_gemma":[0.00003519643,0.000994,0.008323799,0.000008002674,0.00003511227,0.0005997958,0.00003807169,0.0002611308,0.9888882,0.00003134297,0.0007802969,0.000004975152],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952225,0.001236827,0.001183389,0.00009625496,0.00004671025,0.00004083562,0.0003814422,0.0001288938,0.001663094],"genre_scores_gemma":[0.9916487,0.001267438,0.001545692,0.00007858894,0.00001634655,0.0001006783,0.0007378571,0.00003176156,0.004572971],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001634198,"threshold_uncertainty_score":0.005466998,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005839693679883399,"score_gpt":0.2328398772925408,"score_spread":0.2270001836126574,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}