{"id":"W1574067699","doi":"10.1371/journal.pgen.1004409","title":"Aberrant Autolysosomal Regulation Is Linked to The Induction of Embryonic Senescence: Differential Roles of Beclin 1 and p53 in Vertebrate Spns1 Deficiency","year":2014,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"National Institute of General Medical Sciences; National Heart, Lung, and Blood Institute; Fondation pour la Recherche Médicale; National Institute on Aging; National Institutes of Health; Glenn Foundation for Medical Research; Ellison Medical Foundation","keywords":"Autophagy; Senescence; Cell biology; Biology; Autophagosome; Zebrafish; Phenotype; Lysosome; DNA damage; ATG5; Genetics; Apoptosis; Gene; Biochemistry; DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009905926,0.00034035,0.0002753481,0.0003742672,0.000149104,0.0001808447,0.0001579732,0.0004015289,0.0006930583],"category_scores_gemma":[0.00009627338,0.0002125235,0.0002451901,0.00009557782,0.000336789,0.0002661278,0.0002593008,0.0004656597,0.0001788195],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003383426,"about_ca_system_score_gemma":0.0001666478,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006100005,"about_ca_topic_score_gemma":0.0009242328,"domain_scores_codex":[0.9998989,0.00001179843,0.0000145838,0.00003271104,0.00002153382,0.00002039905],"domain_scores_gemma":[0.9998534,0.00001430593,0.00005437414,0.00001244961,0.00001350858,0.00005198951],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000043269,0.000003895064,0.0002225929,0.00001548551,0.000002693168,0.00007847095,0.000009945209,0.00001447917,0.9993067,0.00004042105,0.000006614262,0.0002553627],"study_design_scores_gemma":[0.00001229997,0.0002144063,0.02815006,0.000009479349,0.00002087565,0.0009503848,0.00003694382,0.0006649733,0.9690335,0.00008504582,0.0008142301,0.00000790443],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969554,0.001113229,0.0010946,0.00004948661,0.00001121067,0.00001065739,0.0001758396,0.00006941759,0.0005201905],"genre_scores_gemma":[0.9969656,0.0005288187,0.0008486377,0.00003606378,0.000004349004,0.00002382795,0.0002068532,0.00001570146,0.001370109],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006930583,"threshold_uncertainty_score":0.002454877,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01779310019508089,"score_gpt":0.2564382782920852,"score_spread":0.2386451780970043,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}