{"id":"W1574585714","doi":"10.1038/35078571","title":"The translational inhibitor 4E-BP is an effector of PI(3)K/Akt signalling and cell growth in Drosophila","year":2001,"lang":"en","type":"article","venue":"Nature Cell Biology","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":223,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; McGill University Health Centre","funders":"","keywords":"EIF4E; Cell biology; Biology; Effector; Kinase; Signal transduction; Imaginal disc; Eukaryotic initiation factor; Drosophila melanogaster; Translation (biology); Messenger RNA; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000333721,0.0001991781,0.0002076548,0.00005903083,0.00008191718,0.00001327271,0.0002521018,0.0007865583,0.00002788611],"category_scores_gemma":[0.0000409183,0.0001532441,0.00007828665,0.0001366133,0.0002101925,0.000005394002,0.00004841321,0.0004233288,0.000002720035],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001359339,"about_ca_system_score_gemma":0.00007636117,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001991633,"about_ca_topic_score_gemma":0.00003953748,"domain_scores_codex":[0.9987004,0.0001650178,0.0002769058,0.000453562,0.0001048816,0.0002992144],"domain_scores_gemma":[0.9993567,0.000138492,0.0001155113,0.000210948,0.000105563,0.0000728078],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002571736,0.00006558363,0.01281748,0.00003101628,0.00001629448,0.000003068209,0.00007100267,0.00002746195,0.9856492,0.0001010771,0.0003674319,0.0005931883],"study_design_scores_gemma":[0.001035699,0.000570924,0.001734101,0.00001524882,0.00001581245,0.000007211232,0.00001989434,0.0001175251,0.9784849,0.0008002573,0.01698579,0.0002126766],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9857988,0.0122941,0.0001408746,0.000367398,0.000329035,0.0002059615,0.0000590305,0.000008738091,0.0007960718],"genre_scores_gemma":[0.9976194,0.0007527363,0.0003192539,0.0005394951,0.0004986546,0.00001649384,0.0001427203,0.00002316485,0.00008811374],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01661836,"threshold_uncertainty_score":0.6249111,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006325284953804736,"score_gpt":0.24378749224646,"score_spread":0.2374622072926552,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}