{"id":"W1574601717","doi":"10.3233/jad-2012-112189","title":"ABCG2- and ABCG4-Mediated Efflux of Amyloid-β Peptide 1-40 at the Mouse Blood-Brain Barrier","year":2012,"lang":"en","type":"article","venue":"Journal of Alzheimer s Disease","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":105,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Banting Research Foundation","keywords":"Blood–brain barrier; Efflux; Abcg2; Peptide; Amyloid (mycology); Chemistry; Amyloid β; Neuroscience; Pharmacology; Medicine; Transporter; Biochemistry; Biology; Internal medicine; Central nervous system; Pathology; ATP-binding cassette transporter; Gene; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006265608,0.0002017294,0.0004384957,0.0001252079,0.00009813975,0.00001185024,0.0001306019,0.00007344647,0.0004630798],"category_scores_gemma":[0.0001435055,0.0001172979,0.0003010008,0.000138706,0.0002110007,0.0001846458,0.00003348946,0.000262206,0.00002182266],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001937198,"about_ca_system_score_gemma":0.0001687379,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005739011,"about_ca_topic_score_gemma":0.000004744823,"domain_scores_codex":[0.9983025,0.00007038587,0.0005858643,0.0001268692,0.0005769383,0.0003374661],"domain_scores_gemma":[0.9980131,0.0001225491,0.0003798635,0.0003007162,0.0001802141,0.001003506],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.009119087,0.003259857,0.5839556,0.000605383,0.007554346,0.0009542783,0.004403183,0.00003344643,0.3389246,0.0004961686,0.04854887,0.002145164],"study_design_scores_gemma":[0.009622918,0.0006236435,0.8268084,0.000443162,0.01473048,0.0003462922,0.000898506,0.00003811606,0.1080389,0.0001769639,0.03775683,0.0005157453],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9720501,0.02472991,0.00002168797,0.002364869,0.0002406283,0.0002415684,0.00006631373,0.00001304977,0.0002718166],"genre_scores_gemma":[0.9964357,0.0004097531,0.0002280409,0.0009480551,0.0004201488,0.000004428848,0.00002297603,0.00003613701,0.001494784],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2428528,"threshold_uncertainty_score":0.5070399,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0136300937374815,"score_gpt":0.251966263074174,"score_spread":0.2383361693366925,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}