{"id":"W1574772203","doi":"10.1111/bph.12853","title":"Alteration of vascular reactivity in heart failure: role of phosphodiesterases 3 and 4","year":2014,"lang":"en","type":"article","venue":"British Journal of Pharmacology","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"University of California, San Francisco; Ministère de l'Education Nationale, de l'Enseignement Supérieur et de la Recherche; Fondation Leducq","keywords":"Phosphodiesterase 3; Internal medicine; Phosphodiesterase; Endocrinology; Aorta; Thoracic aorta; Endothelium; Medicine; Chemistry; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003766189,0.00005964431,0.0002044769,0.00005646795,0.00002002125,0.000006272109,0.00004774168,0.00007252019,0.00001987067],"category_scores_gemma":[0.00006452307,0.00006639873,0.00006317103,0.00004837241,0.00007810285,0.00001416543,0.00002613848,0.00008273864,1.624378e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007534359,"about_ca_system_score_gemma":0.00003400246,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000489598,"about_ca_topic_score_gemma":0.00006326702,"domain_scores_codex":[0.9992636,0.0001617526,0.0003176544,0.00009457669,0.00008009516,0.00008226386],"domain_scores_gemma":[0.9995201,0.00002836974,0.0002408099,0.00003890463,0.0001379116,0.00003396606],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001411404,0.0001077992,0.006569045,0.0000220374,0.00003737839,0.000002268077,0.00003296565,0.0001939295,0.9827246,0.00000909992,0.001306655,0.008853088],"study_design_scores_gemma":[0.001484398,0.0003800014,0.04082873,0.00004662187,0.00002992336,0.0003088182,0.00003974585,0.0001719499,0.9395632,0.0000786601,0.01700465,0.00006332899],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967101,0.002338143,0.0005566737,0.000121313,0.0001785363,0.00006281753,0.000004396862,0.000001078735,0.00002698435],"genre_scores_gemma":[0.9985921,0.0005980704,0.0005496575,0.0001123312,0.0001230233,0.000001807235,0.000007024155,0.000005738761,0.00001025154],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04316143,"threshold_uncertainty_score":0.2707661,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004195050156207058,"score_gpt":0.2368306839895276,"score_spread":0.2326356338333205,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}