{"id":"W1574772544","doi":"10.1593/neo.101722","title":"Association between Polymorphisms in Cancer-Related Genes and Early Onset of Esophageal Adenocarcinoma","year":2011,"lang":"en","type":"article","venue":"Neoplasia","topic":"Esophageal Cancer Research and Treatment","field":"Medicine","cited_by":61,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Ontario Institute for Cancer Research; University of Toronto","funders":"National Center for Research Resources; National Cancer Institute; National Institutes of Health; Broad Institute; National Institute of Environmental Health Sciences; Canadian Institutes of Health Research; Flight Attendant Medical Research Institute; Princess Margaret Hospital Foundation; Massachusetts General Hospital","keywords":"Single-nucleotide polymorphism; Esophageal cancer; Oncology; Biology; Genotype; Logistic regression; Haplotype; Internal medicine; Cancer; Esophageal adenocarcinoma; Adenocarcinoma; Gene; Bioinformatics; Genetics; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001494098,0.0001107038,0.0002950195,0.0001567794,0.00002741446,0.000005334224,0.0000513011,0.0001206903,0.0001930585],"category_scores_gemma":[0.00002659485,0.00009799306,0.00004543889,0.0002059473,0.00003631127,0.00006510263,0.00002779194,0.0001676369,0.00001524482],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00025328,"about_ca_system_score_gemma":0.0001571254,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005661868,"about_ca_topic_score_gemma":0.0003318453,"domain_scores_codex":[0.9989781,0.00005274708,0.0002426665,0.0001944564,0.0002715535,0.0002605069],"domain_scores_gemma":[0.9994957,0.00006291659,0.0001035819,0.000133604,0.0000530425,0.0001511234],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001364308,0.0001032103,0.9928328,0.0000349182,0.0002177109,0.0001685056,0.001280076,9.069594e-8,0.0000723366,0.00002676522,0.00006827284,0.005058919],"study_design_scores_gemma":[0.002164663,0.0006784829,0.9858586,0.00005219852,0.0001425622,0.00001602183,0.00001970265,0.000005066359,0.01084765,0.0001452222,0.00001231409,0.00005751819],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9870792,0.01157472,7.144878e-7,0.000247225,0.00004320687,0.0003137395,0.00003777899,0.00002736745,0.0006760741],"genre_scores_gemma":[0.998796,0.0003093361,0.0001943722,0.00001968012,0.00004266654,0.00003526218,0.00001223658,0.00001501337,0.0005754258],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01171683,"threshold_uncertainty_score":0.8559089,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03169605114050111,"score_gpt":0.2893119019150109,"score_spread":0.2576158507745098,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}