{"id":"W1574902133","doi":"10.1038/nri1257","title":"T-cell development made simple","year":2004,"lang":"en","type":"review","venue":"Nature reviews. Immunology","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":315,"is_retracted":false,"has_abstract":false,"ca_institutions":"Health Sciences Centre; Women's College Hospital; University of Toronto; Sunnybrook Health Science Centre","funders":"National Cancer Institute; Canadian Institutes of Health Research","keywords":"Lymphopoiesis; Cell biology; Thymocyte; Extracellular matrix; Function (biology); Biology; Stem cell; Cellular differentiation; Receptor; Chemistry; T cell; Haematopoiesis; Immunology; Biochemistry; Gene; Immune system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":["research_integrity","insufficient_payload"],"category_scores_codex":[0.00118141,0.001059004,0.006004905,0.00066082,0.0001389071,0.00003322783,0.0008820309,0.003380901,0.006636133],"category_scores_gemma":[0.0003746388,0.0007502059,0.001522182,0.001061692,0.000206236,0.00004758103,0.0003892873,0.006787135,0.004656053],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001688314,"about_ca_system_score_gemma":0.003039025,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001060315,"about_ca_topic_score_gemma":0.000003828094,"domain_scores_codex":[0.9948633,0.0006656511,0.001770733,0.001075775,0.0005336382,0.001090861],"domain_scores_gemma":[0.9969083,0.0002445369,0.0006845054,0.001749119,0.0001859122,0.0002276204],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002939968,0.0001886166,7.96778e-7,0.05830568,0.0005046154,0.0001471853,0.00003777243,1.116125e-8,0.000112778,0.00008912229,0.005105504,0.9354785],"study_design_scores_gemma":[0.0008897245,0.0001967982,0.000003684997,0.02661093,0.0006859532,0.001094409,0.000004159112,2.744924e-8,0.0001022959,0.0000306777,0.9698132,0.0005681668],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000001921599,0.9867931,0.00001456214,0.0001041355,0.0006650032,0.004614844,0.00001465985,0.0001207888,0.007671002],"genre_scores_gemma":[7.145483e-7,0.9701222,0.001593079,0.0003670277,0.0003959416,0.0006435478,0.001026941,0.0002103675,0.02564017],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9647077,"threshold_uncertainty_score":0.9994949,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05349645198295755,"score_gpt":0.3988182439844727,"score_spread":0.3453217920015151,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}