{"id":"W1575158876","doi":"10.1111/j.1471-4159.2011.07288.x","title":"Regulation of P‐glycoprotein by orphan nuclear receptors in human brain microvessel endothelial cells","year":2011,"lang":"en","type":"article","venue":"Journal of Neurochemistry","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":77,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Pregnane X receptor; P-glycoprotein; Microvessel; Pharmacology; Receptor; Nuclear receptor; Constitutive androstane receptor; Blood–brain barrier; Biology; Cell biology; Endocrinology; Biochemistry; Cancer research; Transcription factor; Central nervous system; Gene; Multiple drug resistance; Angiogenesis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002436939,0.0001270243,0.0003070374,0.0001819796,0.0002117097,0.0003549545,0.0001320819,0.0001752782,0.001190812],"category_scores_gemma":[0.0002438947,0.0001089604,0.0002271828,0.0003281247,0.0001330754,0.0001831042,0.0001188878,0.0003373974,0.0004131329],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003364819,"about_ca_system_score_gemma":0.0002159284,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003140514,"about_ca_topic_score_gemma":0.002812907,"domain_scores_codex":[0.9997053,0.00009601507,0.00002152601,0.00004362992,0.00007561081,0.0000579705],"domain_scores_gemma":[0.9999206,0.00002330762,0.00001596571,0.00001346687,0.00001925287,0.000007294767],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002155987,0.00005906716,0.0005817745,0.00006960562,0.0000154771,0.0002398184,0.0001499353,0.0001037352,0.992555,0.0004769564,0.0002828599,0.005250187],"study_design_scores_gemma":[0.00006870566,0.001019283,0.02127868,0.00001768473,0.00007128659,0.001286701,0.0002363985,0.003214334,0.9567372,0.0002912291,0.01575535,0.00002312731],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9836535,0.00758033,0.005265355,0.0002570442,0.00005043221,0.00003240578,0.000572696,0.000094714,0.002493501],"genre_scores_gemma":[0.9862826,0.00440718,0.004689128,0.00009854184,0.00002202478,0.00007236898,0.001222753,0.00001381334,0.003191679],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003140514,"threshold_uncertainty_score":0.006244481,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0102809547598973,"score_gpt":0.2182193604016936,"score_spread":0.2079384056417963,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}