{"id":"W1575406972","doi":"10.1002/pros.21057","title":"Arachidonic acid activation of intratumoral steroid synthesis during prostate cancer progression to castration resistance","year":2009,"lang":"en","type":"article","venue":"The Prostate","topic":"Cancer, Lipids, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Arachidonic acid; LNCaP; Androgen receptor; Androgen; Endocrinology; Prostate cancer; Internal medicine; Cancer research; Steroidogenic acute regulatory protein; Chemistry; Biology; Hormone; Biochemistry; Cancer; Medicine; Gene expression; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001829514,0.0001461514,0.0001498242,0.00003791929,0.0001203889,0.00003088007,0.0001444498,0.00005223459,0.000005411155],"category_scores_gemma":[0.00005111753,0.0001090205,0.00004965975,0.0001375516,0.00004901702,0.00001584768,0.00003616795,0.00008564665,0.00000193613],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002922075,"about_ca_system_score_gemma":0.00009907191,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002158277,"about_ca_topic_score_gemma":0.0001206804,"domain_scores_codex":[0.9990082,0.0000682177,0.0002394142,0.0002719787,0.0001625608,0.0002495797],"domain_scores_gemma":[0.9993574,0.00000575038,0.0001702455,0.0003054944,0.0001028283,0.00005825506],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001185645,0.00003706758,0.0002721263,0.00004243979,0.00001545171,9.116629e-8,0.0006187116,0.000149281,0.9746349,0.00003357189,0.0007870357,0.02222368],"study_design_scores_gemma":[0.0003474944,0.0001412431,0.02387279,0.000128927,0.0000213283,0.000002572527,0.00008746887,0.000009108489,0.9664765,0.00009380442,0.008674986,0.0001437711],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959357,0.001056576,0.0001004236,0.001485023,0.0005397305,0.0006549398,0.00004459078,0.0000164729,0.0001665024],"genre_scores_gemma":[0.9966422,0.0005138035,0.0003741745,0.0001397325,0.001296215,0.0001576277,0.00002269518,0.00001614135,0.0008374408],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02360067,"threshold_uncertainty_score":0.4445725,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006848732247618541,"score_gpt":0.2611188359312424,"score_spread":0.2542701036836238,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}