{"id":"W1575406972","doi":"10.1002/pros.21057","title":"Arachidonic acid activation of intratumoral steroid synthesis during prostate cancer progression to castration resistance","year":2009,"lang":"en","type":"article","venue":"The Prostate","topic":"Cancer, Lipids, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Arachidonic acid; LNCaP; Androgen receptor; Androgen; Endocrinology; Prostate cancer; Internal medicine; Cancer research; Steroidogenic acute regulatory protein; Chemistry; Biology; Hormone; Biochemistry; Cancer; Medicine; Gene expression; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001016482,0.000194361,0.0001501591,0.000396817,0.000146904,0.0003061488,0.0001016104,0.0001466012,0.0009922709],"category_scores_gemma":[0.0001140728,0.0000682699,0.0001731385,0.0002761373,0.0001535519,0.0001458571,0.0001255618,0.0002811749,0.0002440969],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004050281,"about_ca_system_score_gemma":0.0002838799,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001308485,"about_ca_topic_score_gemma":0.001313349,"domain_scores_codex":[0.9999253,0.00001098588,0.00000460961,0.00001304174,0.00002789998,0.00001817758],"domain_scores_gemma":[0.9998976,0.0000123131,0.00003318065,0.000008253332,0.00001893355,0.00002974671],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008316372,0.00003514222,0.007900518,0.00007346465,0.00001732851,0.0002403047,0.00004867553,0.00007844181,0.9862332,0.00006978356,0.00008774977,0.004383672],"study_design_scores_gemma":[0.00002851514,0.0009828589,0.2732269,0.00001683785,0.00007340483,0.001741298,0.0002053636,0.001222103,0.7186284,0.0001985692,0.003662141,0.00001359436],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933552,0.003894507,0.0009945319,0.00008146698,0.00001352189,0.00002335212,0.0004980547,0.00006494723,0.001074478],"genre_scores_gemma":[0.9976696,0.0008477663,0.0003400262,0.00002453047,0.000005591294,0.00001229157,0.0004251428,0.000004569544,0.0006704462],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001308485,"threshold_uncertainty_score":0.003319442,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006848732247618541,"score_gpt":0.2611188359312424,"score_spread":0.2542701036836238,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}