{"id":"W1575487625","doi":"10.1186/ar2109","title":"Effect of cyclooxygenase inhibition on cholesterol efflux proteins and atheromatous foam cell transformation in THP-1 human macrophages: a possible mechanism for increased cardiovascular risk","year":2007,"lang":"en","type":"article","venue":"Arthritis Research & Therapy","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institutes of Health; School of Medicine, New York University; York University; National Heart, Lung, and Blood Institute; Scleroderma Foundation; American Diabetes Association","keywords":"ABCA1; Cholesterol; Reverse cholesterol transport; Cyclooxygenase; Foam cell; Downregulation and upregulation; Prostanoid; Inflammation; Pharmacology; Prostaglandin E2; Chemistry; Internal medicine; Prostaglandin; Endocrinology; Medicine; Enzyme; Transporter; Biochemistry; Lipoprotein","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003181133,0.0003520336,0.0004316402,0.00018164,0.0002069925,0.0002194249,0.0001285025,0.0002752744,0.001713977],"category_scores_gemma":[0.0001344587,0.0001777904,0.0003090409,0.0001556248,0.0002566007,0.0001189498,0.0001390678,0.0005050217,0.0004097326],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002076121,"about_ca_system_score_gemma":0.000269647,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007508905,"about_ca_topic_score_gemma":0.001027758,"domain_scores_codex":[0.9997904,0.00005869543,0.00001911127,0.00002482857,0.00004378019,0.00006330023],"domain_scores_gemma":[0.9998307,0.00005578019,0.0000292969,0.00002405133,0.00002881885,0.00003123699],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008425763,0.0001514651,0.0003077623,0.00006840014,0.00001128606,0.0001016585,0.00003721327,0.00002181689,0.9970337,0.00004050213,0.00005751323,0.001326191],"study_design_scores_gemma":[0.000101764,0.001640808,0.006875384,0.000007873991,0.00004064697,0.0002120839,0.00004224706,0.0003998512,0.9890795,0.00003334657,0.001561077,0.000005380904],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993226,0.004174843,0.0007251442,0.0002009956,0.00009915543,0.0000340172,0.0003037718,0.00002551579,0.001210703],"genre_scores_gemma":[0.9927645,0.002777102,0.00170076,0.0001344761,0.0000665484,0.00007000907,0.0004822217,0.00000900499,0.001995271],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001713977,"threshold_uncertainty_score":0.005733848,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01508030717576409,"score_gpt":0.3079265687142833,"score_spread":0.2928462615385192,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}