{"id":"W1576718627","doi":"10.1002/iub.1210","title":"Biochemical and structural aspects of the ATP‐binding domain in inflammasome‐forming human NLRP proteins","year":2013,"lang":"en","type":"review","venue":"IUBMB Life","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":85,"is_retracted":false,"has_abstract":true,"ca_institutions":"Libin Cardiovascular Institute of Alberta; University of Calgary","funders":"","keywords":"Pyrin domain; Inflammasome; Subfamily; Biology; Cyclic nucleotide-binding domain; Homology modeling; Computational biology; Homology (biology); Sequence alignment; Binding site; Cell biology; Peptide sequence; Receptor; Genetics; Biochemistry; Amino acid; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001791529,0.0003832621,0.0007500455,0.0001047716,0.0001071303,0.00003414416,0.0004469718,0.0004913168,0.00002024908],"category_scores_gemma":[0.0001360373,0.0002659163,0.0002956763,0.0001874576,0.0002065551,0.000008447963,0.0003315698,0.0003551035,0.000006196084],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000334019,"about_ca_system_score_gemma":0.0002296086,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003809644,"about_ca_topic_score_gemma":0.00002253999,"domain_scores_codex":[0.9983023,0.0001099954,0.0006518216,0.0004050386,0.0001631373,0.0003676823],"domain_scores_gemma":[0.9989607,0.00001536775,0.0004005949,0.000513994,0.00004010438,0.00006922272],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006581844,0.000145604,0.00251795,0.02992091,0.001238275,0.00002010905,0.001392766,0.000004153505,0.5772957,0.004071263,0.001223909,0.3821036],"study_design_scores_gemma":[0.001012933,0.0001632684,0.0004302596,0.004373145,0.0001785508,0.00004647929,0.0002084034,0.000001529267,0.03901103,0.0003453833,0.9532841,0.0009449376],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.3551073,0.6430628,0.000001039631,0.00001940244,0.00009382202,0.0009096079,0.00001463179,0.000005382572,0.0007860284],"genre_scores_gemma":[0.07739957,0.9208928,0.0001686715,0.00006441006,0.0004115363,0.0002770941,0.0003272914,0.0001102954,0.0003482966],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9520602,"threshold_uncertainty_score":0.9999793,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01564255764468749,"score_gpt":0.2790318733382524,"score_spread":0.2633893156935649,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}