{"id":"W1576718627","doi":"10.1002/iub.1210","title":"Biochemical and structural aspects of the ATP‐binding domain in inflammasome‐forming human NLRP proteins","year":2013,"lang":"en","type":"review","venue":"IUBMB Life","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":85,"is_retracted":false,"has_abstract":true,"ca_institutions":"Libin Cardiovascular Institute of Alberta; University of Calgary","funders":"","keywords":"Pyrin domain; Inflammasome; Subfamily; Biology; Cyclic nucleotide-binding domain; Homology modeling; Computational biology; Homology (biology); Sequence alignment; Binding site; Cell biology; Peptide sequence; Receptor; Genetics; Biochemistry; Amino acid; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002389241,0.0006864789,0.0009291862,0.001184994,0.0002213606,0.0005064891,0.0004635913,0.0007965713,0.001025028],"category_scores_gemma":[0.0002278221,0.0003103654,0.0003499657,0.001740035,0.0005923558,0.001019051,0.0003900587,0.001152236,0.001693359],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004887272,"about_ca_system_score_gemma":0.0005511882,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007044973,"about_ca_topic_score_gemma":0.0006186515,"domain_scores_codex":[0.9998859,0.00001325062,0.00002049578,0.0000241432,0.00004427679,0.00001200462],"domain_scores_gemma":[0.9999217,0.0000200849,0.00002106285,0.000004718232,0.00002288414,0.000009499058],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001333809,0.00009764842,0.000281045,0.01538252,0.00005511725,0.0006888789,0.0001148232,0.00109779,0.04509094,0.007434636,0.009979844,0.9196434],"study_design_scores_gemma":[0.00002339531,0.0001903877,0.002340613,0.001348592,0.0001151339,0.005240158,0.0001037367,0.0002676711,0.01437177,0.0049245,0.9710284,0.00004561921],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0006803318,0.9968606,0.0004918333,0.0001442503,0.0001647317,0.000005540726,0.00002215398,0.00001028761,0.001620241],"genre_scores_gemma":[0.002715555,0.9953577,0.000604112,0.000118022,0.0001374108,0.000007462163,0.00005757749,0.00000207316,0.001000105],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001184994,"threshold_uncertainty_score":0.003546,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01564255764468749,"score_gpt":0.2790318733382524,"score_spread":0.2633893156935649,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}